Global trends in hepatocellular carcinoma epidemiology: implications for screening, prevention and therapy

AG Singal, F Kanwal, JM Llovet - Nature reviews Clinical oncology, 2023 - nature.com
Hepatocellular carcinoma (HCC) mortality rates are increasing globally, and particularly in
the Western world. Cirrhosis remains the predominant risk factor for HCC. However …

Hepatocellular carcinoma surveillance—Utilization, barriers and the impact of changing aetiology

DQ Huang, AG Singal, F Kanwal… - Nature Reviews …, 2023 - nature.com
Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide.
Surveillance for HCC is critical for early detection and treatment, but fewer than one-quarter …

AASLD practice guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma

AG Singal, JM Llovet, M Yarchoan, N Mehta… - Hepatology, 2023 - journals.lww.com
This guidance document provides an updated approach to the prevention, diagnosis, and
treatment of hepatocellular carcinoma (HCC). The prior American Association for the Study …

[HTML][HTML] Epidemiology of liver cirrhosis and associated complications: Current knowledge and future directions

YB Liu, MK Chen - World journal of gastroenterology, 2022 - ncbi.nlm.nih.gov
Cirrhosis causes a heavy global burden. In this review, we summarized up-to-date
epidemiological features of cirrhosis and its complications. Recent epidemiological studies …

Blood-based biomarkers for hepatocellular carcinoma screening: Approaching the end of the ultrasound era?

ND Parikh, N Tayob, AG Singal - Journal of hepatology, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, in
part because of inadequate early detection strategies. Current recommendations for …

[PDF][PDF] International Liver Cancer Association (ILCA) white paper on biomarker development for hepatocellular carcinoma

AG Singal, Y Hoshida, DJ Pinato, J Marrero, JC Nault… - Gastroenterology, 2021 - Elsevier
International Liver Cancer Association (ILCA) White Paper on Biomarker Development for
Hepatocellular Carcinoma Page 1 1 International Liver Cancer Association (ILCA) White Paper …

Validation of a novel multitarget blood test shows high sensitivity to detect early stage hepatocellular carcinoma

NP Chalasani, K Porter, A Bhattacharya… - Clinical …, 2022 - Elsevier
Background & Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer-related
death worldwide. Although biannual ultrasound surveillance with or without α-fetoprotein …

GALAD demonstrates high sensitivity for HCC surveillance in a cohort of patients with cirrhosis

AG Singal, N Tayob, A Mehta, JA Marrero… - …, 2022 - Wiley Online Library
Abstract Background and Aims Most patients with HCC are diagnosed at a late stage,
highlighting the need for more accurate surveillance tests. Although biomarkers for HCC …

Barriers to surveillance for hepatocellular carcinoma in a multicenter cohort

ND Parikh, N Tayob, T Al-Jarrah, J Kramer… - JAMA network …, 2022 - jamanetwork.com
Importance Hepatocellular carcinoma (HCC) surveillance is underused in clinical practice,
which may be owing to patient and clinician barriers. Objective To characterize HCC …

Conceptual model for the hepatocellular carcinoma screening continuum: current status and research agenda

AG Singal, AS Lok, Z Feng, F Kanwal… - Clinical Gastroenterology …, 2022 - Elsevier
Hepatocellular carcinoma (HCC) continues to have a dismal prognosis, with 5-year survival
below 20%. This poor prognosis can be in part attributed to failures along the cancer …