The adult ventricular–subventricular zone (V-SVZ) and olfactory bulb (OB) neurogenesis

DA Lim, A Alvarez-Buylla - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
A large population of neural stem/precursor cells (NSCs) persists in the ventricular–
subventricular zone (V-SVZ) located in the walls of the lateral brain ventricles. V-SVZ NSCs …

The development and functions of multiciliated epithelia

N Spassky, A Meunier - Nature reviews Molecular cell biology, 2017 - nature.com
Multiciliated cells are epithelial cells that are in contact with bodily fluids and are required for
the proper function of major organs including the brain, the respiratory system and the …

Reversing behavioural abnormalities in mice exposed to maternal inflammation

Y Shin Yim, A Park, J Berrios, M Lafourcade… - Nature, 2017 - nature.com
Viral infection during pregnancy is correlated with increased frequency of
neurodevelopmental disorders, and this is studied in mice prenatally subjected to maternal …

[HTML][HTML] Adult neural stem cells bridge their niche

LC Fuentealba, K Obernier, A Alvarez-Buylla - Cell stem cell, 2012 - cell.com
Major developments in the neural stem cell (NSC) field in recent years provide new insights
into the nature of the NSC niche. In this perspective, we integrate recent anatomical data on …

[HTML][HTML] Single-cell transcriptomics and fate mapping of ependymal cells reveals an absence of neural stem cell function

PT Shah, JA Stratton, MG Stykel, S Abbasi, S Sharma… - Cell, 2018 - cell.com
Ependymal cells are multi-ciliated cells that form the brain's ventricular epithelium and a
niche for neural stem cells (NSCs) in the ventricular-subventricular zone (V-SVZ). In …

Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4

EJ Benner, D Luciano, R Jo, K Abdi, P Paez-Gonzalez… - Nature, 2013 - nature.com
Postnatal/adult neural stem cells (NSCs) within the rodent subventricular zone (SVZ; also
called subependymal zone) generate doublecortin (Dcx)+ neuroblasts that migrate and …

Reactive astrocytes as neural stem or progenitor cells: in vivo lineage, in vitro potential, and genome‐wide expression analysis

M Götz, S Sirko, J Beckers, M Irmler - Glia, 2015 - Wiley Online Library
Here, we review the stem cell hallmarks of endogenous neural stem cells (NSCs) during
development and in some niches of the adult mammalian brain to then compare these with …

Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy

O Basak, TG Krieger, MJ Muraro… - Proceedings of the …, 2018 - National Acad Sciences
The adult mouse subependymal zone provides a niche for mammalian neural stem cells
(NSCs). However, the molecular signature, self-renewal potential, and fate behavior of …

Structure and function of the ependymal barrier and diseases associated with ependyma disruption

AJ Jiménez, MD Domínguez-Pinos, MM Guerra… - Tissue …, 2014 - Taylor & Francis
The neuroepithelium is a germinal epithelium containing progenitor cells that produce
almost all of the central nervous system cells, including the ependyma. The neuroepithelium …

Adult neural stem cells stake their ground

DA Lim, A Alvarez-Buylla - Trends in neurosciences, 2014 - cell.com
The birth of new neurons in the walls of the adult brain lateral ventricles has captured the
attention of many neuroscientists for over 2 decades, yielding key insights into the identity …