Kisspeptins and reproduction: physiological roles and regulatory mechanisms

L Pinilla, E Aguilar, C Dieguez, RP Millar… - Physiological …, 2012 - journals.physiology.org
Procreation is essential for survival of species. Not surprisingly, complex neuronal networks
have evolved to mediate the diverse internal and external environmental inputs that regulate …

[HTML][HTML] Comprehensive review on kisspeptin and its role in reproductive disorders

H Clarke, WS Dhillo, CN Jayasena - Endocrinology and …, 2015 - ncbi.nlm.nih.gov
Kisspeptin has recently emerged as a key regulator of the mammalian reproductive axis. It is
known that kisspeptin, acting centrally via the kisspeptin receptor, stimulates secretion of …

Potential roles for the kisspeptin/kisspeptin receptor system in implantation and placentation

KL Hu, HM Chang, HC Zhao, Y Yu… - Human reproduction …, 2018 - academic.oup.com
BACKGROUND Initially identified as suppressors of metastasis in various types of cancer,
kisspeptins are a family of neuropeptides that are key regulators of the mammalian …

[HTML][HTML] A role for placental kisspeptin in β cell adaptation to pregnancy

JE Bowe, TG Hill, KF Hunt, LIF Smith, SJS Simpson… - JCI insight, 2019 - ncbi.nlm.nih.gov
During pregnancy the maternal pancreatic islets of Langerhans undergo adaptive changes
to compensate for gestational insulin resistance. Kisspeptin has been shown to stimulate …

Reduced levels of plasma kisspeptin during the antenatal booking visit are associated with increased risk of miscarriage

CN Jayasena, A Abbara… - The Journal of …, 2014 - academic.oup.com
Context: Kisspeptin is a recently identified hormone encoded by the KISS1 gene, playing a
critical role in human reproduction. Plasma kisspeptin levels rise dramatically during normal …

[HTML][HTML] Kisspeptin as a new serum biomarker to discriminate miscarriage from viable intrauterine pregnancy

C Sullivan-Pyke, DJ Haisenleder, S Senapati… - Fertility and sterility, 2018 - Elsevier
Objective To validate the ability of serum kisspeptin-54 to discriminate between first-trimester
viable pregnancies and miscarriages. Design Case-control study. Setting Academic medical …

[HTML][HTML] Kisspeptin in the prediction of pregnancy complications

J Tsoutsouki, B Patel, AN Comninos… - Frontiers in …, 2022 - frontiersin.org
Kisspeptin and its receptor are central to reproductive health acting as key regulators of the
reproductive endocrine axis in humans. Kisspeptin is most widely recognised as a regulator …

[HTML][HTML] The role of kisspeptin in the pathogenesis of pregnancy complications: a narrative review

M Szydełko-Gorzkowicz… - International Journal of …, 2022 - mdpi.com
Kisspeptins are the family of neuropeptide products of the KISS-1 gene that exert the
biological action by binding with the G-protein coupled receptor 54 (GPR54), also known as …

Kisspeptin as a potential biomarker throughout pregnancy

KL Hu, H Zhao, Y Yu, R Li - European Journal of Obstetrics & Gynecology …, 2019 - Elsevier
Kisspeptins are a family of neuropeptides that are critical for the puberty initiation and female
fertility. Plasma or serum kisspeptin is mainly derived from the placenta during pregnancy …

Evaluation of kisspeptin levels in obese pregnancy as a biomarker for pre‐eclampsia

JJ Logie, FC Denison, SC Riley… - Clinical …, 2012 - Wiley Online Library
Objectives Circulating concentrations of the peptide kisspeptin have been proposed as a
novel biomarker for early detection of pre‐eclampsia. Our aims were to assess analytical …