Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease
JZ Haeggstrom, CD Funk - Chemical reviews, 2011 - ACS Publications
Metabolism of arachidonic acid leads to several families of lipid mediators, including
prostaglandins, thromboxane, leukotrienes, and lipoxins, along two major metabolic …
prostaglandins, thromboxane, leukotrienes, and lipoxins, along two major metabolic …
Multiple phenotypic changes define neutrophil priming
I Miralda, SM Uriarte, KR McLeish - Frontiers in cellular and infection …, 2017 - frontiersin.org
Exposure to pro-inflammatory cytokines, chemokines, mitochondrial contents, and bacterial
and viral products induces neutrophils to transition from a basal state into a primed one …
and viral products induces neutrophils to transition from a basal state into a primed one …
Phagocytosis and innate immunity
S Greenberg, S Grinstein - Current opinion in immunology, 2002 - Elsevier
Phagocytosis is an evolutionarily conserved process utilized by many cells to ingest
microbial pathogens, and apoptotic and necrotic corpses. Recent investigation has revealed …
microbial pathogens, and apoptotic and necrotic corpses. Recent investigation has revealed …
BLT1 and BLT2: the leukotriene B4 receptors
AM Tager, AD Luster - Prostaglandins, leukotrienes and essential fatty …, 2003 - Elsevier
Two receptors for leukotriene B4 (LTB4) have been molecularly identified: BLT1 and BLT2.
Both receptors are G protein-coupled seven transmembrane domain receptors, whose …
Both receptors are G protein-coupled seven transmembrane domain receptors, whose …
Leukotrienes: underappreciated mediators of innate immune responses
Leukotrienes are bronchoconstrictor and vasoactive lipid mediators that are targets in the
treatment of asthma. Although they are increasingly recognized to exert broad …
treatment of asthma. Although they are increasingly recognized to exert broad …
Production of eicosanoids and other oxylipins by pathogenic eukaryotic microbes
MC Noverr, JR Erb-Downward… - Clinical microbiology …, 2003 - Am Soc Microbiol
Oxylipins are oxygenated metabolites of fatty acids. Eicosanoids are a subset of oxylipins
and include the prostaglandins and leukotrienes, which are potent regulators of host …
and include the prostaglandins and leukotrienes, which are potent regulators of host …
Lipoxygenase genes and their targeted disruption
CD Funk, XS Chen, EN Johnson, L Zhao - Prostaglandins & other lipid …, 2002 - Elsevier
Analysis of the human and mouse genome sequences has enabled a detailed analysis of
the structure and organization of the lipoxygenase genes in the respective species. Humans …
the structure and organization of the lipoxygenase genes in the respective species. Humans …
The leukotrienes: immune-modulating lipid mediators of disease
A Di Gennaro, JZ Haeggström - Advances in immunology, 2012 - Elsevier
The leukotrienes are important lipid mediators with immune modulatory and proinflammatory
properties. Classical bioactions of leukotrienes include chemotaxis, endothelial adherence …
properties. Classical bioactions of leukotrienes include chemotaxis, endothelial adherence …
An ACE inhibitor reduces bactericidal activity of human neutrophils in vitro and impairs mouse neutrophil activity in vivo
Angiotensin-converting enzyme inhibitors (ACEIs) are used by millions of patients to treat
hypertension, diabetic kidney disease, and heart failure. However, these patients are often …
hypertension, diabetic kidney disease, and heart failure. However, these patients are often …
Biosynthesis of leukotriene B4
M Wan, X Tang, A Stsiapanava, JZ Haeggström - Seminars in immunology, 2017 - Elsevier
Abstract Leukotriene B 4 (LTB 4) is a lipid mediator derived from arachidonic acid (AA) by
the sequential action of 5-lipoxygenase (5-LOX), 5-lipoxygenase-activating protein (FLAP) …
the sequential action of 5-lipoxygenase (5-LOX), 5-lipoxygenase-activating protein (FLAP) …