FOXP2 as a molecular window into speech and language

SE Fisher, C Scharff - Trends in Genetics, 2009 - cell.com
Rare mutations of the FOXP2 transcription factor gene cause a monogenic syndrome
characterized by impaired speech development and linguistic deficits. Recent genomic …

Brain mechanisms of acoustic communication in humans and nonhuman primates: An evolutionary perspective

H Ackermann, SR Hage, W Ziegler - Behavioral and Brain Sciences, 2014 - cambridge.org
Any account of “what is special about the human brain”(Passingham 2008) must specify the
neural basis of our unique ability to produce speech and delineate how these remarkable …

Speech perception and language acquisition in the first year of life

J Gervain, J Mehler - Annual review of psychology, 2010 - annualreviews.org
During the first year of life, infants pass important milestones in language development. We
review some of the experimental evidence concerning these milestones in the domains of …

Evo-devo, deep homology and FoxP2: implications for the evolution of speech and language

C Scharff, J Petri - … Transactions of the Royal Society B …, 2011 - royalsocietypublishing.org
The evolution of novel morphological features, such as feathers, involves the modification of
developmental processes regulated by gene networks. The fact that genetic novelty …

FOXP transcription factors in vertebrate brain development, function, and disorders

M Co, AG Anderson, G Konopka - Wiley Interdisciplinary …, 2020 - Wiley Online Library
FOXP transcription factors are an evolutionarily ancient protein subfamily coordinating the
development of several organ systems in the vertebrate body. Association of their genes …

[PDF][PDF] Diminished FoxP2 levels affect dopaminergic modulation of corticostriatal signaling important to song variability

M Murugan, S Harward, C Scharff, R Mooney - Neuron, 2013 - cell.com
Mutations of the FOXP2 gene impair speech and language development in humans and
shRNA-mediated suppression of the avian ortholog FoxP2 disrupts song learning in juvenile …

Core and region-enriched networks of behaviorally regulated genes and the singing genome

O Whitney, AR Pfenning, JT Howard, CA Blatti, F Liu… - Science, 2014 - science.org
INTRODUCTION Brain activity drives both behavior and regulated gene expression in
neurons. Although past studies have identified activity-induced signaling and gene …

Molecular networks implicated in speech-related disorders: FOXP2 regulates the SRPX2/uPAR complex

P Roll, SC Vernes, N Bruneau, J Cillario… - Human molecular …, 2010 - academic.oup.com
It is a challenge to identify the molecular networks contributing to the neural basis of human
speech. Mutations in transcription factor FOXP2 cause difficulties mastering fluent speech …

[PDF][PDF] Molecular microcircuitry underlies functional specification in a basal ganglia circuit dedicated to vocal learning

AT Hilliard, JE Miller, ER Fraley, S Horvath, SA White - Neuron, 2012 - cell.com
Similarities between speech and birdsong make songbirds advantageous for investigating
the neurogenetics of learned vocal communication—a complex phenotype probably …

The role of the FOXP family of transcription factors in ASD

JM Bowers, G Konopka - Disease markers, 2012 - content.iospress.com
Autism spectrum disorders (ASD) is a neurodevelopmental disease with complex genetics;
however, the genes that are responsible for this disease still remain mostly unknown. Here …