Epigenetic modifications control chromatin structure and function, and thus mediate changes
in gene expression, ultimately influencing protein levels. Recent research indicates that …

Although homocysteine (Hcy) has been widely implicated in the etiology of various physical
health impairments, especially cardiovascular diseases, overwhelming evidence indicates …

The gut microbiome has been linked to fear extinction learning in animal models. Here, we
aimed to explore the gut microbiome and memory domains according to obesity status. A …

Background: Evidence remains unclear as to whether folic acid (FA) and vitamin B-12
supplementation is effective in reducing depressive symptoms. Objectives: The objective …

There is strong evidence that homocysteine is a risk factor not only for cerebrovascular
diseases but also for degenerative dementias. A recent consensus statement renewed the …

Experimental and epidemiological studies have shown the close relationship between
stressful events, depression, and cognitive impairment. Folic acid has been reported to …

The heritability of major depression has been documented in a number of epidemiologic
studies. Twin studies have estimated the heritability at about 37% and these estimation can …

Chronic administration of L-methionine leads to memory impairment, which is attributed to
increase in the level of oxidative stress in the brain. On the other hand, metformin is a …

Typically the monoamine system has been the central focus of neurobiological research into
depression and represents the major target of modern antidepressant medications; although …

Homocysteine (Hcy) is a sulfur-containing amino acid derived from methionine metabolism.
Elevated plasma Hcy levels (> 15 µM) result in a condition called hyperhomocysteinemia …