Voltage-gated potassium channels as therapeutic targets
The human genome encodes 40 voltage-gated K+ channels (KV), which are involved in
diverse physiological processes ranging from repolarization of neuronal and cardiac action …
diverse physiological processes ranging from repolarization of neuronal and cardiac action …
[HTML][HTML] Mitochondrial channels: ion fluxes and more
I Szabo, M Zoratti - Physiological reviews, 2014 - journals.physiology.org
The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …
molecular identification of some of the channels. An integrative approach using genetics …
Distinct inflammatory Th17 subsets emerge in autoimmunity and infection
Th17 cells play a critical role in both tissue homeostasis and inflammation during clearance
of infections as well as autoimmune and inflammatory disorders. Despite numerous efforts to …
of infections as well as autoimmune and inflammatory disorders. Despite numerous efforts to …
The functional network of ion channels in T lymphocytes
MD Cahalan, KG Chandy - Immunological reviews, 2009 - Wiley Online Library
For more than 25 years, it has been widely appreciated that Ca2+ influx is essential to
trigger T‐lymphocyte activation. Patch clamp analysis, molecular identification, and …
trigger T‐lymphocyte activation. Patch clamp analysis, molecular identification, and …
Molecular basis of calcium signaling in lymphocytes: STIM and ORAI
Ca2+ entry into cells of the peripheral immune system occurs through highly Ca2+-selective
channels known as CRAC (calcium release-activated calcium) channels. CRAC channels …
channels known as CRAC (calcium release-activated calcium) channels. CRAC channels …
Clofazimine: current status and future prospects
Clofazimine, a lipophilic riminophenazine antibiotic, possesses both antimycobacterial and
anti-inflammatory activities. However, its efficacy has been demonstrated only in the …
anti-inflammatory activities. However, its efficacy has been demonstrated only in the …
[HTML][HTML] Reduction of clofazimine by mycobacterial type 2 NADH: quinone oxidoreductase: a pathway for the generation of bactericidal levels of reactive oxygen …
T Yano, S Kassovska-Bratinova, JS Teh… - Journal of Biological …, 2011 - ASBMB
The mechanism of action of clofazimine (CFZ), an antimycobacterial drug with a long history,
is not well understood. The present study describes a redox cycling pathway that involves …
is not well understood. The present study describes a redox cycling pathway that involves …
Bactericidal activity of pyrazinamide and clofazimine alone and in combinations with pretomanid and bedaquiline
AH Diacon, R Dawson… - American journal of …, 2015 - atsjournals.org
Rationale: New regimens to shorten tuberculosis treatment and manage patients with drug-
resistant tuberculosis who are infected with HIV are urgently needed. Experimental and …
resistant tuberculosis who are infected with HIV are urgently needed. Experimental and …
[HTML][HTML] Direct pharmacological targeting of a mitochondrial ion channel selectively kills tumor cells in vivo
The potassium channel Kv1. 3 is highly expressed in the mitochondria of various cancerous
cells. Here we show that direct inhibition of Kv1. 3 using two mitochondria-targeted inhibitors …
cells. Here we show that direct inhibition of Kv1. 3 using two mitochondria-targeted inhibitors …
Potassium channels in Parkinson's disease: potential roles in its pathogenesis and innovative molecular targets for treatment
Parkinson's disease (PD) is a neurodegenerative disorder characterized by selective loss of
dopaminergic neurons in the substantia nigra pars compacta (SNpc) region of the midbrain …
dopaminergic neurons in the substantia nigra pars compacta (SNpc) region of the midbrain …