Novel therapeutic strategies: Targeting epithelial–mesenchymal transition in colorectal cancer

N Zhang, AS Ng, S Cai, Q Li, L Yang, D Kerr - The lancet oncology, 2021 - thelancet.com
Epithelial–mesenchymal transition (EMT) is a process during which cells lose their epithelial
characteristics, for instance apical–basal cell polarity and cell–cell contact, and gain …

New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer

A Dongre, RA Weinberg - Nature reviews Molecular cell biology, 2019 - nature.com
Epithelial–mesenchymal transition (EMT) is a cellular programme that is known to be crucial
for embryogenesis, wound healing and malignant progression. During EMT, cell–cell and …

Context-dependent EMT programs in cancer metastasis

NM Aiello, Y Kang - Journal of Experimental Medicine, 2019 - rupress.org
Epithelial–mesenchymal transition (EMT) is a developmental process whereby stationary,
adherent cells acquire the ability to migrate. EMT is critical for dramatic cellular movements …

Regulation of EMT in colorectal cancer: a culprit in metastasis

T Vu, PK Datta - Cancers, 2017 - mdpi.com
Epithelial to mesenchymal transition (EMT) is a process during which cells lose their
epithelial characteristics, for instance cell polarity and cell–cell contact, and gain …

Epithelial–mesenchymal transition in colorectal cancer metastasis: a system review

H Cao, E Xu, H Liu, L Wan, M Lai - Pathology-Research and Practice, 2015 - Elsevier
Tumor metastasis is a multi-step process by which tumor cells disseminate from their primary
site and form secondary tumors at a distant site. And metastasis is the major cause of death …

EMT-activating transcription factors in cancer: beyond EMT and tumor invasiveness

E Sánchez-Tilló, Y Liu, O de Barrios, L Siles… - Cellular and molecular …, 2012 - Springer
Cancer is a complex multistep process involving genetic and epigenetic changes that
eventually result in the activation of oncogenic pathways and/or inactivation of tumor …

ZEB/miR‐200 feedback loop: at the crossroads of signal transduction in cancer

L Hill, G Browne, E Tulchinsky - International journal of cancer, 2013 - Wiley Online Library
Embryonic differentiation programs of epithelial–mesenchymal and mesenchymal–epithelial
transition (EMT and MET) represent a mechanistic basis for epithelial cell plasticity …

An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance

N Li, R Babaei-Jadidi, F Lorenzi, B Spencer-Dene… - Oncogenesis, 2019 - nature.com
Colorectal cancer (CRC) patients develop recurrence after chemotherapy owing to the
survival of stem cell-like cells referred to as cancer stem-like cells (CSCs). The origin of …

Antagonistic effects of p53 and HIF1A on microRNA-34a regulation of PPP1R11 and STAT3 and hypoxia-induced epithelial to mesenchymal transition in colorectal …

H Li, M Rokavec, L Jiang, D Horst, H Hermeking - Gastroenterology, 2017 - Elsevier
Background & Aims In colorectal tumors, hypoxia causes resistance to therapy and
promotes metastasis. Loss of the tumor suppressor p53 (encoded by TP53) provides cancer …

Concise review: stem cells and epithelial-mesenchymal transition in cancer: biological implications and therapeutic targets

R Sato, T Semba, H Saya, Y Arima - Stem cells, 2016 - academic.oup.com
Cancer stem cells (CSCs) constitute a small subpopulation of cancer cells with stem-like
properties that are able to self-renew, generate differentiated daughter cells, and give rise to …