Benefiting from a higher volumetric capacity (3833 mA h cm− 3 for Mg vs. 2046 mA h cm− 3
for Li) and dendrite-free Mg metal anode, reversible Mg batteries (RMBs) are a promising …

The repair of DNA damage is a complex process that relies on particular pathways to
remedy specific types of damage to DNA. The range of insults to DNA includes small …

Protein–protein interactions (PPI) were once considered 'undruggable', but clinical
successes, driven by advanced methods in drug discovery, have challenged that notion …

Protein ADP-ribosylation is essential for the regulation of several cellular pathways,
enabling dynamic responses to diverse pathophysiological conditions. It is modulated …

The efficient delivery of bioactive compounds into cells is a major challenge in drug
discovery. We report herein the development of novel methods for intracellular delivery of …

Pioneer transcription factors (TFs) function as genomic first responders, binding to
inaccessible regions of chromatin to promote enhancer formation. The mechanism by which …

Major advances have recently defined functions for human mono-ADP-ribosylating PARP
enzymes (mono-ARTs), also opening up potential applications for targeting them to treat …

The adenomatous polyposis coli (APC)–Rho guanine nucleotide exchange factor 4 (Asef)
protein–protein interaction (PPI) is essential for colorectal cancer metastasis, making it a …

The search for new therapeutic targets and their implications in drug development remains
an emerging scientific topic. BRCT-bearing proteins are found in Archaea, Bacteria …

Chiral amino acids featuring a phosphonate pendant arm are an important type of
biologically active scaffold. Here in this review, we comprehensively summarize the modern …