Liquid‐assisted grinding mechanochemistry in the synthesis of pharmaceuticals
P Ying, J Yu, W Su - Advanced Synthesis & Catalysis, 2021 - Wiley Online Library
Mechanochemical reactions by milling, grinding or other types of mechanical action have
emerged as a salient green approach because of its wide applications towards academic …
emerged as a salient green approach because of its wide applications towards academic …
Pharmaceutical and medicinal significance of sulfur (SVI)-Containing motifs for drug discovery: A critical review
Sulfur (S VI) based moieties, especially, the sulfonyl or sulfonamide based analogues have
showed a variety of pharmacological properties, and its derivatives propose a high degree …
showed a variety of pharmacological properties, and its derivatives propose a high degree …
Recent advances in the asymmetric synthesis of pharmacology-relevant nitrogen heterocycles via stereoselective aza-Michael reactions
MG Vinogradov, OV Turova, SG Zlotin - Organic & Biomolecular …, 2019 - pubs.rsc.org
The prevalence of nitrogen containing heterocycles in natural products and pharmaceuticals
is a doubtless fact. In this review, recent applications of a stereoselective aza-Michael …
is a doubtless fact. In this review, recent applications of a stereoselective aza-Michael …
Some recent approaches of biologically active substituted pyridazine and phthalazine drugs
M Asif - Current medicinal chemistry, 2012 - ingentaconnect.com
Nitrogen atom containing heterocyclic compounds, pyridazines, pyridazinones and
phthalazines are important structural feature of many biologically active compounds and …
phthalazines are important structural feature of many biologically active compounds and …
Discovery of 3, 6-disubstituted pyridazines as a novel class of anticancer agents targeting cyclin-dependent kinase 2: synthesis, biological evaluation and in silico …
A Sabt, WM Eldehna, T Al-Warhi… - Journal of Enzyme …, 2020 - Taylor & Francis
Human health in the current medical era is facing numerous challenges, especially cancer.
So, the therapeutic arsenal for cancer should be unremittingly enriched with novel small …
So, the therapeutic arsenal for cancer should be unremittingly enriched with novel small …
The therapeutic journey of pyridazinone
Pyridazinones have drawn a substantial attention within the field of research analysis and
development. The moiety is a subject matter of intensive research because of its wide …
development. The moiety is a subject matter of intensive research because of its wide …
A new pyridazinone exhibits potent cytotoxicity on human cancer cells via apoptosis and poly-ubiquitinated protein accumulation
DA Gutierrez, RE DeJesus, L Contreras… - Cell biology and …, 2019 - Springer
In the last 15 years, pyridazinone derivatives have acquired extensive attention due to their
widespread biological activities and pharmacological applications. Pyridazinones are well …
widespread biological activities and pharmacological applications. Pyridazinones are well …
Pyridazinone: an important element of pharmacophore possessing broad spectrum of activity
S Dubey, PA Bhosle - Medicinal Chemistry Research, 2015 - Springer
In the last few years, the pyridazine derivatives have been found to exhibit a wide range of
pharmacological activities. A large number of research articles and patents described them …
pharmacological activities. A large number of research articles and patents described them …
Microwave-assisted one pot three-component synthesis of novel bioactive thiazolyl-pyridazinediones as potential antimicrobial agents against antibiotic-resistant …
S Abu-Melha, SM Gomha, AS Abouzied, MM Edrees… - Molecules, 2021 - mdpi.com
Pyridazine and thiazole derivatives have various biological activities such as antimicrobial,
analgesic, anticancer, anticonvulsant, antitubercular and other anticipated biological …
analgesic, anticancer, anticonvulsant, antitubercular and other anticipated biological …
[HTML][HTML] Elucidation of potential anticancer, antioxidant and antimicrobial properties of some new triazole compounds bearing pyridine-4-yl moiety and cyclobutane …
Abstract Thiosemicarbazides (2a–e) were obtained by the interaction of pyridine-4-
carboxylic acid hydrazide (1) with five different isothiocyanate (RNCS) derivatives. By …
carboxylic acid hydrazide (1) with five different isothiocyanate (RNCS) derivatives. By …