Liquid‐assisted grinding mechanochemistry in the synthesis of pharmaceuticals

P Ying, J Yu, W Su - Advanced Synthesis & Catalysis, 2021 - Wiley Online Library
Mechanochemical reactions by milling, grinding or other types of mechanical action have
emerged as a salient green approach because of its wide applications towards academic …

Pharmaceutical and medicinal significance of sulfur (SVI)-Containing motifs for drug discovery: A critical review

C Zhao, KP Rakesh, L Ravidar, WY Fang… - European journal of …, 2019 - Elsevier
Sulfur (S VI) based moieties, especially, the sulfonyl or sulfonamide based analogues have
showed a variety of pharmacological properties, and its derivatives propose a high degree …

Recent advances in the asymmetric synthesis of pharmacology-relevant nitrogen heterocycles via stereoselective aza-Michael reactions

MG Vinogradov, OV Turova, SG Zlotin - Organic & Biomolecular …, 2019 - pubs.rsc.org
The prevalence of nitrogen containing heterocycles in natural products and pharmaceuticals
is a doubtless fact. In this review, recent applications of a stereoselective aza-Michael …

Some recent approaches of biologically active substituted pyridazine and phthalazine drugs

M Asif - Current medicinal chemistry, 2012 - ingentaconnect.com
Nitrogen atom containing heterocyclic compounds, pyridazines, pyridazinones and
phthalazines are important structural feature of many biologically active compounds and …

Discovery of 3, 6-disubstituted pyridazines as a novel class of anticancer agents targeting cyclin-dependent kinase 2: synthesis, biological evaluation and in silico …

A Sabt, WM Eldehna, T Al-Warhi… - Journal of Enzyme …, 2020 - Taylor & Francis
Human health in the current medical era is facing numerous challenges, especially cancer.
So, the therapeutic arsenal for cancer should be unremittingly enriched with novel small …

The therapeutic journey of pyridazinone

W Akhtar, M Shaquiquzzaman, M Akhter… - European journal of …, 2016 - Elsevier
Pyridazinones have drawn a substantial attention within the field of research analysis and
development. The moiety is a subject matter of intensive research because of its wide …

A new pyridazinone exhibits potent cytotoxicity on human cancer cells via apoptosis and poly-ubiquitinated protein accumulation

DA Gutierrez, RE DeJesus, L Contreras… - Cell biology and …, 2019 - Springer
In the last 15 years, pyridazinone derivatives have acquired extensive attention due to their
widespread biological activities and pharmacological applications. Pyridazinones are well …

Pyridazinone: an important element of pharmacophore possessing broad spectrum of activity

S Dubey, PA Bhosle - Medicinal Chemistry Research, 2015 - Springer
In the last few years, the pyridazine derivatives have been found to exhibit a wide range of
pharmacological activities. A large number of research articles and patents described them …

Microwave-assisted one pot three-component synthesis of novel bioactive thiazolyl-pyridazinediones as potential antimicrobial agents against antibiotic-resistant …

S Abu-Melha, SM Gomha, AS Abouzied, MM Edrees… - Molecules, 2021 - mdpi.com
Pyridazine and thiazole derivatives have various biological activities such as antimicrobial,
analgesic, anticancer, anticonvulsant, antitubercular and other anticipated biological …

[HTML][HTML] Elucidation of potential anticancer, antioxidant and antimicrobial properties of some new triazole compounds bearing pyridine-4-yl moiety and cyclobutane …

P Koparir, AE Parlak, A Karatepe, RA Omar - Arabian Journal of Chemistry, 2022 - Elsevier
Abstract Thiosemicarbazides (2a–e) were obtained by the interaction of pyridine-4-
carboxylic acid hydrazide (1) with five different isothiocyanate (RNCS) derivatives. By …