Thiazole: A versatile standalone moiety contributing to the development of various drugs and biologically active agents
For many decades, the thiazole moiety has been an important heterocycle in the world of
chemistry. The thiazole ring consists of sulfur and nitrogen in such a fashion that the pi (π) …
chemistry. The thiazole ring consists of sulfur and nitrogen in such a fashion that the pi (π) …
Recent applications of 1, 3-thiazole core structure in the identification of new lead compounds and drug discovery
Thiazole is one of the most important scaffolds in heterocyclic chemistry and drug design
and discovery. It is widely found in diverse pharmacologically active substances and in …
and discovery. It is widely found in diverse pharmacologically active substances and in …
Synthesis, biological evaluation, and molecular docking of novel azolylhydrazonothiazoles as potential anticancer agents
A novel set of thiazolylhydrazonothiazoles bearing an indole moiety were synthesized by
subjection reactions of carbothioamide derivative and hydrazonoyl chlorides (or α …
subjection reactions of carbothioamide derivative and hydrazonoyl chlorides (or α …
Efficient synthesis, antibacterial, antifungal, antioxidant and cytotoxicity study of 2‐(2‐hydrazineyl) thiazole derivatives
VA Adole, RA More, BS Jagdale, TB Pawar… - …, 2020 - Wiley Online Library
In the present investigation, an alluring green PEG‐400 mediated one‐pot synthesis of
novel 2‐(2‐hydrazinyl) thiazole derivatives from 1, 2, 6, 7‐tetrahydro‐8H‐indeno [5, 4‐b] …
novel 2‐(2‐hydrazinyl) thiazole derivatives from 1, 2, 6, 7‐tetrahydro‐8H‐indeno [5, 4‐b] …
Novel indole-thiazolidinone conjugates: Design, synthesis and whole-cell phenotypic evaluation as a novel class of antimicrobial agents
In connection with our research program on the development of novel anti-tubercular
candidates, herein we report the design and synthesis of two different sets of indole …
candidates, herein we report the design and synthesis of two different sets of indole …
Novel thiadiazole-thiazole hybrids: synthesis, molecular docking, and cytotoxicity evaluation against liver cancer cell lines
One of the worst diseases, cancer claims millions of lives each year throughout the world,
necessitating the creation of novel treatments. In this study, we designed a novel series of 1 …
necessitating the creation of novel treatments. In this study, we designed a novel series of 1 …
Indole chalcones: Design, synthesis, in vitro and in silico evaluation against Mycobacterium tuberculosis
Indole chalcones were designed and synthesized as a promising set of compounds against
H 37 Rv strain of Mycobacterium tuberculosis. Within this library of compounds,(E)-1-(furan …
H 37 Rv strain of Mycobacterium tuberculosis. Within this library of compounds,(E)-1-(furan …
A review on recent synthetic strategies and pharmacological importance of 1, 3-thiazole derivatives
S Nayak, SL Gaonkar - Mini reviews in medicinal chemistry, 2019 - ingentaconnect.com
Thiazole is the most common heterocyclic compound in heterocyclic chemistry and in drug
design. Presence of several reaction sites in the thiazole moiety extends their range of …
design. Presence of several reaction sites in the thiazole moiety extends their range of …
Design, synthesis, biological evaluation, QSAR analysis and molecular modelling of new thiazol-benzimidazoles as EGFR inhibitors
AM Srour, NS Ahmed, SS Abd El-Karim… - Bioorganic & Medicinal …, 2020 - Elsevier
Heterocyclic rings such as thiazole and benzimidazole are considered as privileged
structures, since they constitute several FDA-approved drugs for cancer treatment. In this …
structures, since they constitute several FDA-approved drugs for cancer treatment. In this …
Synthesis, in vitro evaluation and molecular docking studies of novel thiophenyl thiazolyl-pyridine hybrids as potential anticancer agents
FO Ashmawy, SM Gomha, MA Abdallah, MEA Zaki… - Molecules, 2023 - mdpi.com
Many literature reports revealed the anticancer activity of pyridine and thiazole derivatives,
especially in lung cancer. Therefore, a new series of thiazolyl pyridines linked with …
especially in lung cancer. Therefore, a new series of thiazolyl pyridines linked with …