How cancer hijacks the body's homeostasis through the neuroendocrine system
During oncogenesis, cancer not only escapes the body's regulatory mechanisms, but also
gains the ability to affect local and systemic homeostasis. Specifically, tumors produce …
gains the ability to affect local and systemic homeostasis. Specifically, tumors produce …
[HTML][HTML] Melatonin: a cutaneous perspective on its production, metabolism, and functions
AT Slominski, R Hardeland, MA Zmijewski… - Journal of Investigative …, 2018 - Elsevier
Melatonin, an evolutionarily ancient derivative of serotonin with hormonal properties, is the
main neuroendocrine secretory product of the pineal gland. Although melatonin is best …
main neuroendocrine secretory product of the pineal gland. Although melatonin is best …
The serum vitamin D metabolome: What we know and what is still to discover
RC Tuckey, CYS Cheng, AT Slominski - The Journal of steroid biochemistry …, 2019 - Elsevier
Vitamin D, referring to the two forms, D2 from the diet and D3 primarily derived from
phototransformation in the skin, is a prohormone important in human health. The most …
phototransformation in the skin, is a prohormone important in human health. The most …
[HTML][HTML] Role of Vitamins in Pathogenesis and Treatment of Cancers
S Poudineh, M Poudineh, R Roohinezhad, R Khorram… - Kindle, 2023 - preferpub.org
Vitamins with antioxidant characteristics have been shown as potential chemopreventive
agents because of their roles in quenching free radicals and decreasing oxidative damage …
agents because of their roles in quenching free radicals and decreasing oxidative damage …
Novel activities of CYP11A1 and their potential physiological significance
CYP11A1, found only in vertebrates, catalyzes the first step of steroidogenesis where
cholesterol is converted to pregnenolone. The purified enzyme, also converts desmosterol …
cholesterol is converted to pregnenolone. The purified enzyme, also converts desmosterol …
Extra-adrenal glucocorticoid biosynthesis: implications for autoimmune and inflammatory disorders
RM Slominski, RC Tuckey, PR Manna, AM Jetten… - Genes & …, 2020 - nature.com
Glucocorticoid synthesis is a complex, multistep process that starts with cholesterol being
delivered to the inner membrane of mitochondria by StAR and StAR-related proteins. Here …
delivered to the inner membrane of mitochondria by StAR and StAR-related proteins. Here …
[HTML][HTML] RORα and ROR γ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy-and 20, 23-dihydroxyvitamin D
AT Slominski, TK Kim, Y Takeda, Z Janjetovic… - The FASEB …, 2014 - ncbi.nlm.nih.gov
RORα and RORγ are expressed in human skin cells that produce the noncalcemic 20-
hydroxyvitamin D 3 [20 (OH) D 3] and 20, 23-dihydroxyvitamin D 3 [20, 23 (OH) 2 D 3] …
hydroxyvitamin D 3 [20 (OH) D 3] and 20, 23-dihydroxyvitamin D 3 [20, 23 (OH) 2 D 3] …
Neuroendocrine aspects of skin aging
G Bocheva, RM Slominski, AT Slominski - International journal of …, 2019 - mdpi.com
Skin aging is accompanied by a gradual loss of function, physiological integrity and the
ability to cope with internal and external stressors. This is secondary to a combination of …
ability to cope with internal and external stressors. This is secondary to a combination of …
The significance of CYP11A1 expression in skin physiology and pathology
RM Slominski, C Raman, C Elmets, AM Jetten… - Molecular and cellular …, 2021 - Elsevier
CYP11A1, a member of the cytochrome P450 family, plays several key roles in the human
body. It catalyzes the first and rate-limiting step in steroidogenesis, converting cholesterol to …
body. It catalyzes the first and rate-limiting step in steroidogenesis, converting cholesterol to …
The role of melanogenesis in regulation of melanoma behavior: Melanogenesis leads to stimulation of HIF-1α expression and HIF-dependent attendant pathways
A Slominski, TK Kim, AA Brożyna, Z Janjetovic… - Archives of biochemistry …, 2014 - Elsevier
To study the effect of melanogenesis on HIF-1α expression and attendant pathways, we
used stable human and hamster melanoma cell lines in which the amelanotic vs. melanotic …
used stable human and hamster melanoma cell lines in which the amelanotic vs. melanotic …