During oncogenesis, cancer not only escapes the body's regulatory mechanisms, but also
gains the ability to affect local and systemic homeostasis. Specifically, tumors produce …

Melatonin, an evolutionarily ancient derivative of serotonin with hormonal properties, is the
main neuroendocrine secretory product of the pineal gland. Although melatonin is best …

Vitamin D, referring to the two forms, D2 from the diet and D3 primarily derived from
phototransformation in the skin, is a prohormone important in human health. The most …

Vitamins with antioxidant characteristics have been shown as potential chemopreventive
agents because of their roles in quenching free radicals and decreasing oxidative damage …

CYP11A1, found only in vertebrates, catalyzes the first step of steroidogenesis where
cholesterol is converted to pregnenolone. The purified enzyme, also converts desmosterol …

Glucocorticoid synthesis is a complex, multistep process that starts with cholesterol being
delivered to the inner membrane of mitochondria by StAR and StAR-related proteins. Here …

RORα and RORγ are expressed in human skin cells that produce the noncalcemic 20-
hydroxyvitamin D 3 [20 (OH) D 3] and 20, 23-dihydroxyvitamin D 3 [20, 23 (OH) 2 D 3] …

Skin aging is accompanied by a gradual loss of function, physiological integrity and the
ability to cope with internal and external stressors. This is secondary to a combination of …

CYP11A1, a member of the cytochrome P450 family, plays several key roles in the human
body. It catalyzes the first and rate-limiting step in steroidogenesis, converting cholesterol to …

To study the effect of melanogenesis on HIF-1α expression and attendant pathways, we
used stable human and hamster melanoma cell lines in which the amelanotic vs. melanotic …