Histone H2AX phosphorylation on a serine four residues from the carboxyl terminus
(producing γH2AX) is a sensitive marker for DNA double-strand breaks (DSBs). DSBs may …

Gammaherpesviruses are lymphotropic viruses that are associated with the development of
lymphoproliferative diseases, lymphomas, as well as other nonlymphoid cancers. Most …

Kaposi sarcoma herpesvirus (KSHV), taxonomical name human gammaherpesvirus 8, is a
phylogenetically old human virus that co-evolved with human populations, but is now only …

The EBV is a human gamma‐herpesvirus that is associated with a variety of neoplasms.
Upon primary infection, it transiently runs a short lytic program and then predominantly …

The papillomavirus E1 and E2 proteins are essential for viral genome replication. E1 is a
helicase that unwinds the viral origin and recruits host cellular factors to replicate the viral …

It is clear that a number of host-cell factors facilitate virus replication and, conversely, a
number of other factors possess inherent antiviral activity. Research, particularly over the …

The cellular surveillance network for sensing and repairing damaged DNA prevents an array
of human diseases, and when compromised it can lead to genomic instability and cancer …

Populations in developed countries continue to grow older and an understanding of the
ageing process to allow healthy ageing carries important medical implications. Older …

Abstract The Epstein–Barr virus (EBV) is a human gamma‐herpesvirus that is implicated in
various types of proliferative diseases. Upon infection, it predominantly establishes latency …

Herpesviruses, which are major human pathogens, establish life-long persistent infections.
Although the α, β, and γ herpesviruses infect different tissues and cause distinct diseases …