Since the discovery of the RET receptor tyrosine kinase in 1985, alterations of this protein
have been found in diverse thyroid cancer subtypes. RET gene rearrangements are …

Background The incidence of thyroid cancer has increased in different populations
worldwide in the past 30 years. We present here an overview of international trends of …

Genetic variability in humans is influenced by many factors, such as natural selection,
mutations, genetic drift, and migrations. Molecular epidemiology evaluates the contribution …

Context Early genetic association studies yielded too high risk estimates for multiple
endocrine neoplasia (MEN2A), suggesting a need for extended surgery. Objective The …

Background The impact of number of node metastases versus metastatic lymph node ratio
versus AJCC node category on biochemical cure in medullary thyroid cancer (MTC) is not …

Background Serum calcitonin level is a useful biomarker for predicting primary tumor size,
the extent of lymph node, and distant metastasis in patients with medullary thyroid …

Background: Survival of medullary thyroid carcinoma (MTC) subgroups in relation to the
general population is poorly described. Data on the factors predicting long-term biochemical …

Context Risk factors of lymph node and distant metastases have rarely been analyzed in
hereditary and sporadic medullary thyroid cancer (MTC) using large genetic-clinical data …

Objective The c. 1998delinsTTCT variant in the RET gene (codon 666) is linked to medullary
thyroid carcinoma in Belgium. We aimed to study the clinical phenotype and the age …

Background Thyroid cancer is becoming increasingly common worldwide, but little is known
about the epidemiology of medullary thyroid carcinoma (MTC). This study investigated the …