This paper is the forty-fifth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

The functional interplay between the corticolimbic GABAergic and opioidergic systems plays
a crucial role in regulating the reward system and cognitive aspects of motivational …

Chronic opioid intake leads to several brain changes involved in the development of
dependence, whereby an early hedonistic effect (liking) extends to the need to self …

The present study investigates the possible therapeutic effects of human mesenchymal stem
cell-derived secretome on morphine dependence and relapse. This was studied in a new …

Maternal morphine exposure reduces motivation for basic cognitive tasks, followed by
executive function deficits in attention and accuracy. It also induces depression‐like …

Chronic opioid treatments dysregulate the glutamatergic system, inducing a
hyperglutamatergic state in mesocorticolimbic brain regions. This study investigated the …

To re-examine the paradoxical effect hypothesis of abused drugs, the present study
concerned whether different doses of morphine disparately affect neuronal activity and …

Chronic exposure to opioids can lead to downregulation of astrocytic glutamate transporter 1
(GLT-1), which regulates the majority of glutamate uptake. Studies from our lab revealed that …

Background Morphine is an opiate commonly used in the treatment of moderate to severe
pain. However, prolonged administration can lead to physical dependence and strong …

Background Experimental evidence indicates that Naloxone (NLX) holds antioxidant
properties. The present study aims at verifying the hypothesis that NLX could prevent …