Recent advances and limitations of mTOR inhibitors in the treatment of cancer

ES Ali, K Mitra, S Akter, S Ramproshad, B Mondal… - Cancer cell …, 2022 - Springer
Abstract The PI3K-Akt-mechanistic (formerly mammalian) target of the rapamycin (mTOR)
signaling pathway is important in a variety of biological activities, including cellular …

Pyroptosis, ferroptosis, and autophagy cross-talk in glioblastoma opens up new avenues for glioblastoma treatment

S Wan, G Zhang, R Liu, MN Abbas, H Cui - Cell Communication and …, 2023 - Springer
Glioma is a common primary tumor of the central nervous system (CNS), with glioblastoma
multiforme (GBM) being the most malignant, aggressive, and drug resistant. Most drugs are …

Allicin attenuates pathological cardiac hypertrophy by inhibiting autophagy via activation of PI3K/Akt/mTOR and MAPK/ERK/mTOR signaling pathways

L Ba, J Gao, Y Chen, H Qi, C Dong, H Pan, Q Zhang… - Phytomedicine, 2019 - Elsevier
Background Cardiac hypertrophy is an adaptive response of the myocardium to pressure or
volume overload. Recent evidences indicate that allicin can prevent cardiac hypertrophy …

Natural compounds as promising adjuvant agents in the treatment of gliomas

F Persano, G Gigli, S Leporatti - International Journal of Molecular …, 2022 - mdpi.com
In humans, glioblastoma is the most prevalent primary malignant brain tumor. Usually,
glioblastoma has specific characteristics, such as aggressive cell proliferation and rapid …

LncRNA NEAT1 knockdown attenuates autophagy to elevate 5‐FU sensitivity in colorectal cancer via targeting miR‐34a

F Liu, FY Ai, DC Zhang, L Tian, ZY Yang… - Cancer …, 2020 - Wiley Online Library
Backgrounds Colorectal carcinoma (CRC) is a common malignant tumor. Increasing
evidences indicated that CRC showed a resistance to 5‐fluorouracil (5‐FU) and further …

Nanomedicines targeting glioma stem cells

A Sabu, TI Liu, SS Ng, RA Doong… - … Applied Materials & …, 2022 - ACS Publications
Glioblastoma (GBM), classified as a grade IV glioma, is a rapidly growing, aggressive, and
most commonly occurring tumor of the central nervous system. Despite the therapeutic …

Targeting glioblastoma stem cells to overcome chemoresistance: an overview of current therapeutic strategies

H Kang, H Lee, D Kim, B Kim, JH Kang, HY Kim… - Biomedicines, 2022 - mdpi.com
Glioblastoma (GBM) is the most malignant primary brain tumor. The current standard
approach in GBM is surgery, followed by treatment with radiation and temozolomide (TMZ); …

The multi-faceted effect of curcumin in glioblastoma from rescuing cell clearance to autophagy-independent effects

L Ryskalin, F Biagioni, CL Busceti, G Lazzeri, A Frati… - Molecules, 2020 - mdpi.com
The present review focuses on the multi-faceted effects of curcumin on the neurobiology
glioblastoma multiforme (GBM), with a special emphasis on autophagy (ATG)-dependent …

The autophagy status of cancer stem cells in gliobastoma multiforme: from cancer promotion to therapeutic strategies

L Ryskalin, A Gaglione, F Limanaqi, F Biagioni… - International journal of …, 2019 - mdpi.com
Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor
featuring rapid cell proliferation, treatment resistance, and tumor relapse. This is largely due …

Autophagy regulation on cancer stem cell maintenance, metastasis, and therapy resistance

X Wang, J Lee, C Xie - Cancers, 2022 - mdpi.com
Simple Summary Certain types of cancer have higher relapse rates compared to others, and
cancer stem cells (CSCs) have been shown as the main drivers of cancer relapse and …