The molecular basis for cellular function of intrinsically disordered protein regions
AS Holehouse, BB Kragelund - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Intrinsically disordered protein regions exist in a collection of dynamic interconverting
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …
Intrinsically disordered regions are poised to act as sensors of cellular chemistry
Intrinsically disordered proteins and protein regions (IDRs) are abundant in eukaryotic
proteomes and play a wide variety of essential roles. Instead of folding into a stable …
proteomes and play a wide variety of essential roles. Instead of folding into a stable …
Increasing the resilience of plant immunity to a warming climate
Extreme weather conditions associated with climate change affect many aspects of plant
and animal life, including the response to infectious diseases. Production of salicylic acid …
and animal life, including the response to infectious diseases. Production of salicylic acid …
The material properties of a bacterial-derived biomolecular condensate tune biological function in natural and synthetic systems
Intracellular phase separation is emerging as a universal principle for organizing
biochemical reactions in time and space. It remains incompletely resolved how biological …
biochemical reactions in time and space. It remains incompletely resolved how biological …
Condensation of SEUSS promotes hyperosmotic stress tolerance in Arabidopsis
B Wang, H Zhang, J Huai, F Peng, J Wu, R Lin… - Nature Chemical …, 2022 - nature.com
Osmotic stress imposed by drought and high salinity inhibits plant growth and crop yield.
However, our current knowledge on the mechanism by which plants sense osmotic stress is …
However, our current knowledge on the mechanism by which plants sense osmotic stress is …
When phased without water: biophysics of cellular desiccation, from biomolecules to condensates
The molecular machinery that enables life has evolved in water, yet many of the organisms
around us are able to survive even extreme desiccation. Especially remarkable are single …
around us are able to survive even extreme desiccation. Especially remarkable are single …
Clustering of aromatic residues in prion-like domains can tune the formation, state, and organization of biomolecular condensates: published as part of the …
In immature oocytes, Balbiani bodies are conserved membraneless condensates implicated
in oocyte polarization, the organization of mitochondria, and long-term organelle and RNA …
in oocyte polarization, the organization of mitochondria, and long-term organelle and RNA …
Stress-related biomolecular condensates in plants
J Solis-Miranda, M Chodasiewicz, A Skirycz… - The Plant …, 2023 - academic.oup.com
Biomolecular condensates are membraneless organelle-like structures that can concentrate
molecules and often form through liquid-liquid phase separation. Biomolecular condensate …
molecules and often form through liquid-liquid phase separation. Biomolecular condensate …
Molecular mechanisms of adaptive evolution in wild animals and plants
Wild animals and plants have developed a variety of adaptive traits driven by adaptive
evolution, an important strategy for species survival and persistence. Uncovering the …
evolution, an important strategy for species survival and persistence. Uncovering the …
Phase separation and molecular ordering of the prion-like domain of the Arabidopsis thermosensory protein EARLY FLOWERING 3
S Hutin, JR Kumita, VI Strotmann… - Proceedings of the …, 2023 - National Acad Sciences
Liquid–liquid phase separation (LLPS) is an important mechanism enabling the dynamic
compartmentalization of macromolecules, including complex polymers such as proteins and …
compartmentalization of macromolecules, including complex polymers such as proteins and …