Throughout the ages, Nature has catered to the basic needs of humans, not the least of
which is the provision of medicines for the treatment of a wide spectrum of diseases. Plants …

Drug discovery from marine natural products has enjoyed a renaissance in the past few
years. Ziconotide (Prialt; Elan Pharmaceuticals), a peptide originally discovered in a tropical …

Marine natural products - Natural Product Reports (RSC Publishing) DOI:10.1039/B006897G
Royal Society of Chemistry View PDF VersionPrevious ArticleNext Article DOI: 10.1039/B006897G …

This Account provides an overview and examples of function-oriented synthesis (FOS) and
its increasingly important role in producing therapeutic leads that can be made in a step …

In recent years, marine natural product bioprospecting has yielded a considerable number
of drug candidates. Most of these molecules are still in preclinical or early clinical …

Oxidation reactions are powerful tools to convert a position that is protected in a lower
oxidation state to the desired functionality and for the functionalization of otherwise …

The marine environment has proven to be a very rich source of extremely potent compounds
that have demonstrated significant activities in antitumor, antiinflammatory, analgesia …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

The strong σ-donor but poor π-acceptor abilities of N-heterocyclic carbenes (NHCs) result in
chemical stability and coordination versatility, thus allowing them to coordinate with many …

reductive elimination of the β-acyloxysulfone 4 with a single electron donor to afford alkene
products. All four steps can be carried out in a single reaction vessel, although in practice …