Stroke remains a leading cause of death and disability in the world. Over the past few
decades our understanding of the pathophysiology of stroke has increased, but greater …

There is an increasing recognition that inflammation plays a critical role in
neurodegenerative diseases of the CNS, including Alzheimer's disease, amyotrophic lateral …

Stroke is an acute insult to the central nervous system (CNS) that triggers a sequence of
responses in the acute, subacute as well as later stages, with prominent involvement of …

The anaphylatoxin (AT) C3a, C5a and C5a-desArg are generally considered pro-
inflammatory polypeptides generated after proteolytic cleavage of C3 and C5 in response to …

The brain is considered to be an immune privileged site, because the blood–brain barrier
limits entry of blood borne cells and proteins into the central nervous system (CNS). As a …

The complement system is a set of immune proteins involved in first-line defense against
pathogens and removal of waste materials. Recent evidence has implicated the complement …

Despite significant research on the role of inflammation and immunosurveillance in the
immunologic microenvironment of tumors, little attention has been given to the oncogenic …

Traumatic brain injury (TBI) is an important cause of disability and mortality in the western
world. While the initial injury sustained results in damage, it is the subsequent secondary …

Inflammation of central nervous system (CNS) is usually associated with trauma and
infection. Neuroinflammation occurs in close relation to trauma, infection, and …

The complement system was discovered a century ago as a potent defense cascade of
innate immunity. After its first description, continuous experimental and clinical research was …