[HTML][HTML] Novel stroke therapeutics: unraveling stroke pathophysiology and its impact on clinical treatments
PM George, GK Steinberg - Neuron, 2015 - cell.com
Stroke remains a leading cause of death and disability in the world. Over the past few
decades our understanding of the pathophysiology of stroke has increased, but greater …
decades our understanding of the pathophysiology of stroke has increased, but greater …
[HTML][HTML] CNS inflammation and neurodegeneration
T Chitnis, HL Weiner - The Journal of clinical investigation, 2017 - Am Soc Clin Investig
There is an increasing recognition that inflammation plays a critical role in
neurodegenerative diseases of the CNS, including Alzheimer's disease, amyotrophic lateral …
neurodegenerative diseases of the CNS, including Alzheimer's disease, amyotrophic lateral …
Astrocyte activation and reactive gliosis—a new target in stroke?
Stroke is an acute insult to the central nervous system (CNS) that triggers a sequence of
responses in the acute, subacute as well as later stages, with prominent involvement of …
responses in the acute, subacute as well as later stages, with prominent involvement of …
The role of the anaphylatoxins in health and disease
A Klos, AJ Tenner, KO Johswich, RR Ager, ES Reis… - Molecular …, 2009 - Elsevier
The anaphylatoxin (AT) C3a, C5a and C5a-desArg are generally considered pro-
inflammatory polypeptides generated after proteolytic cleavage of C3 and C5 in response to …
inflammatory polypeptides generated after proteolytic cleavage of C3 and C5 in response to …
Complement in the brain
R Veerhuis, HM Nielsen, AJ Tenner - Molecular immunology, 2011 - Elsevier
The brain is considered to be an immune privileged site, because the blood–brain barrier
limits entry of blood borne cells and proteins into the central nervous system (CNS). As a …
limits entry of blood borne cells and proteins into the central nervous system (CNS). As a …
The complement system in schizophrenia: where are we now and what's next?
The complement system is a set of immune proteins involved in first-line defense against
pathogens and removal of waste materials. Recent evidence has implicated the complement …
pathogens and removal of waste materials. Recent evidence has implicated the complement …
Cancer and the complement cascade
MJ Rutkowski, ME Sughrue, AJ Kane, SA Mills… - Molecular Cancer …, 2010 - AACR
Despite significant research on the role of inflammation and immunosurveillance in the
immunologic microenvironment of tumors, little attention has been given to the oncogenic …
immunologic microenvironment of tumors, little attention has been given to the oncogenic …
[HTML][HTML] The role of the complement system in traumatic brain injury: a review
A Hammad, L Westacott, M Zaben - Journal of neuroinflammation, 2018 - Springer
Traumatic brain injury (TBI) is an important cause of disability and mortality in the western
world. While the initial injury sustained results in damage, it is the subsequent secondary …
world. While the initial injury sustained results in damage, it is the subsequent secondary …
Innate immunity and neuroinflammation
Inflammation of central nervous system (CNS) is usually associated with trauma and
infection. Neuroinflammation occurs in close relation to trauma, infection, and …
infection. Neuroinflammation occurs in close relation to trauma, infection, and …
[HTML][HTML] New insights of an old defense system: structure, function, and clinical relevance of the complement system
C Ehrnthaller, A Ignatius, F Gebhard, M Huber-Lang - Molecular medicine, 2011 - Springer
The complement system was discovered a century ago as a potent defense cascade of
innate immunity. After its first description, continuous experimental and clinical research was …
innate immunity. After its first description, continuous experimental and clinical research was …