In the field of nasal drug delivery, nose-to-brain delivery is among the most fascinating
applications, directly targeting the central nervous system, bypassing the blood brain barrier …

Chitosan is a natural polymer extensively applied in the cosmetic, textile, food, and
agricultural industries. Chitosan possesses biocompatibility, biodegradability, and …

Nose-to-brain delivery is an attractive route for direct drug delivery to the central nervous
system (CNS), avoiding hepatic first-pass metabolism and solving blood–brain barrier …

The blood-brain barrier (BBB) is a sophisticated and very selective dynamic interface
composed of endothelial cells expressing enzymes, transport systems, and receptors that …

In an experiment to explore the bioadhesion, biocompatibility, and membrane permeation
properties, the controlled synthesis of N, N, N-trimethyl chitosan (TMC) was carried out by …

Here we report the development of tristearin-based nanostructured-lipid carriers (NLCs)
which were further surface-modified with mucoadhesive N, N, N-trimethyl chitosan (TMC) to …

Conjugate drugs are evolving into potent techniques in the drug development process for
enhancing the biopharmaceutical, physicochemical, and pharmacokinetic properties …

Aim: The present study evaluates the efficacy of paromomycin (PM)-loaded mannosylated
thiomeric nanoparticles for the targeted delivery to pathological organs for the oral therapy of …

Here we report fabrication and evaluation of novel surface modified polymer–lipid hybrid
nanoparticles (PLN) as robust carriers for intranasal delivery of ropinirole hydrochloride …

In our study, poly (dl-lactide-co-glycolide)(PLGA) nanoparticles loaded with perphenazine
(PPH) and chlorpromazine hydrochloride (CPZ-HCl) were formulated by emulsion solvent …