As an evolutionarily conserved signalling network, the Hippo pathway plays a crucial role in
the regulation of numerous biological processes. Thus, substantial efforts have been made …

Complex physiological processes control whether stem cells self-renew, differentiate or
remain quiescent. Two decades of research have placed the Hippo pathway, a highly …

The Hippo signalling pathway has emerged as a major player in many aspects of liver
biology, such as development, cell fate determination, homeostatic function and …

The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction
has been implicated in an increasing number of human diseases, including cancer. Here …

The turnover of the intestinal epithelium is driven by multipotent LGR5+ crypt-base columnar
cells (CBCs) located at the bottom of crypt zones. However, CBCs are lost following injury …

Background and Aims Activation of the antitumor immune response using programmed
death receptor‐1 (PD‐1) blockade showed benefit only in a fraction of patients with …

Hippo pathway components are structurally and functionally conserved and are notable for
their role in controlling organ size. More diverse functions of the Hippo pathway have been …

Abstract Background Non-coding RNAs (ncRNAs) have been shown to regulate gene
expression involved in tumor progression of multiple malignancies. Our previous studies …

The Hippo signaling pathway is widely considered a master regulator of organ growth
because of the prominent overgrowth phenotypes caused by experimental manipulation of …

Studies of the regenerative capacity of the liver have converged on the Hippo pathway, a
serine/threonine kinase cascade discovered in Drosophila and conserved from unicellular …