Targeting cannabinoid receptors: current status and prospects of natural products
D An, S Peigneur, LA Hendrickx, J Tytgat - International journal of …, 2020 - mdpi.com
Cannabinoid receptors (CB1 and CB2), as part of the endocannabinoid system, play a
critical role in numerous human physiological and pathological conditions. Thus …
critical role in numerous human physiological and pathological conditions. Thus …
Endogenous opiates and behavior: 2014
RJ Bodnar - Peptides, 2016 - Elsevier
This paper is the thirty-seventh consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2014 …
concerning the endogenous opioid system. It summarizes papers published during 2014 …
Intracellular peptides in cell biology and pharmacology
Intracellular peptides are produced by proteasomes following degradation of nuclear,
cytosolic, and mitochondrial proteins, and can be further processed by additional peptidases …
cytosolic, and mitochondrial proteins, and can be further processed by additional peptidases …
OCP002, a mixed agonist of opioid and cannabinoid receptors, produces potent antinociception with minimized side effects
B Xu, Q Zhang, D Chen, M Zhang, R Zhang… - Anesthesia & …, 2023 - journals.lww.com
BACKGROUND: Increasing attention has been attracted to the development of bifunctional
compounds to minimize the side effects of opioid analgesics. Pharmacological studies have …
compounds to minimize the side effects of opioid analgesics. Pharmacological studies have …
Hemopressin as a breakthrough for the cannabinoid field
Hemopressin (PVNFKFLSH in rats, and PVNFKLLSH in humans and mice), a fragment
derived from the α-chain of hemoglobin, was the first peptide described to have type 1 …
derived from the α-chain of hemoglobin, was the first peptide described to have type 1 …
BN‐9, a chimeric peptide with mixed opioid and neuropeptide FF receptor agonistic properties, produces nontolerance‐forming antinociception in mice
Background and Purpose Neuropeptide FF (NPFF) behaves as an endogenous opioid‐
modulating peptide. In the present study, the opioid and NPFF pharmacophore‐containing …
modulating peptide. In the present study, the opioid and NPFF pharmacophore‐containing …
Stress-induced pain: a target for the development of novel therapeutics
AC Johnson, B Greenwood-Van Meerveld - Journal of Pharmacology and …, 2014 - ASPET
Although current therapeutics provide relief from acute pain, drugs used for treatment of
chronic pain are typically less efficacious and limited by adverse side effects, including …
chronic pain are typically less efficacious and limited by adverse side effects, including …
Recent progress in non-opioid analgesic peptides
MJP de Vega, A Ferrer-Montiel… - Archives of biochemistry …, 2018 - Elsevier
Pain is a prevalent complex medical problem, characterized by physically debilitating and
mentally destabilizing conditions. Current pain therapeutics mainly include non-steroidal …
mentally destabilizing conditions. Current pain therapeutics mainly include non-steroidal …
[HTML][HTML] Spinal DN-9, a peptidic multifunctional opioid/neuropeptide FF agonist produced potent nontolerance forming analgesia with limited side effects
The development of multitarget opioid drugs has emerged as an attractive therapeutic
strategy to eliminate opioid-related side effects. Our previous study developed a series of …
strategy to eliminate opioid-related side effects. Our previous study developed a series of …
Emotional disorders induced by Hemopressin and RVD-hemopressin (α) administration in rats
S Leone, L Recinella, A Chiavaroli, S Martinotti… - Pharmacological …, 2017 - Elsevier
Background The endocannabinoid (eCB) system plays an important role in regulating
emotional disorders, and is involved, directly or indirectly, in psychiatric diseases, such as …
emotional disorders, and is involved, directly or indirectly, in psychiatric diseases, such as …