Hexosamine biosynthetic pathway and O-GlcNAc cycling of glucose metabolism in brain function and disease

DY Kim, J Park, IO Han - American Journal of Physiology …, 2023 - journals.physiology.org
Impaired brain glucose metabolism is considered a hallmark of brain dysfunction and
neurodegeneration. Disruption of the hexosamine biosynthetic pathway (HBP) and …

O-GlcNAcylation and Its Roles in Neurodegenerative Diseases

P Du, X Zhang, X Lian, C Hölscher… - Journal of Alzheimer's …, 2024 - content.iospress.com
As a non-classical post-translational modification, O-linked β-N-acetylglucosamine (O-
GlcNAc) modification (O-GlcNAcylation) is widely found in human organ systems …

The Role of Oxygen Homeostasis and the HIF-1 Factor in the Development of Neurodegeneration

EV Mitroshina, MV Vedunova - International Journal of Molecular …, 2024 - mdpi.com
Understanding the molecular underpinnings of neurodegeneration processes is a pressing
challenge for medicine and neurobiology. Alzheimer's disease (AD) and Parkinson's …