Chronic kidney disease (CKD) remains a worldwide public health problem associated with
serious complications and increased mortality rates. Accumulating evidence indicates that …

The presence and progression of numerous diseases have been linked to deficiencies in
antioxidant systems. The relationships between single nucleotide polymorphisms (SNPs) …

The current goal of diabetes therapy is to reduce time-averaged mean levels of glycemia,
measured as HbA1c, to prevent diabetic complications. However, HbA1c only explains< …

Background Microalbuminuria is a common diagnosis in the clinical care of patients with
type 1 diabetes mellitus. Long-term outcomes after the development of microalbuminuria are …

Complications (EDIC) Study (2), are celebrating the 30th anniversary since the start of the
DCCT and 20th since the reporting of the DCCT primary results (3). During the past three …

We examined whether persistence of epigenetic DNA methylation (DNA-me) alterations at
specific loci over two different time points in people with diabetes are associated with …

OBJECTIVE Kidney disease manifests clinically as elevated albumin excretion rate (AER),
impaired glomerular filtration rate (GFR), or both, and is a cause of substantial morbidity and …

Background Diabetic nephropathy is a serious complication of diabetes mellitus and is
associated with considerable morbidity and high mortality. There is increasing evidence to …

OBJECTIVE Despite extensive evidence for genetic susceptibility to diabetic nephropathy,
the identification of susceptibility genes and their variants has had limited success. To …

Background Diabetes is the leading cause of end‐stage kidney disease (ESKD) around the
world. Blood pressure lowering and glucose control are used to reduce diabetes‐associated …