Pathophysiology of chronic graft-versus-host disease and therapeutic targets

R Zeiser, BR Blazar - New England Journal of Medicine, 2017 - Mass Medical Soc
Chronic GVHD, an autoimmune disease that follows allogeneic hematopoietic-cell
transplantation, is characterized by infections and debilitating tissue injury leading to …

[HTML][HTML] The biology of chronic graft-versus-host disease: a task force report from the National Institutes of Health Consensus Development Project on Criteria for …

KR Cooke, L Luznik, S Sarantopoulos, FT Hakim… - Biology of Blood and …, 2017 - Elsevier
Chronic graft-versus-host disease (GVHD) is the leading cause of late, nonrelapse mortality
and disability in allogeneic hematopoietic cell transplantation recipients and a major …

Cytokines in graft-versus-host disease

AS Henden, GR Hill - The Journal of Immunology, 2015 - journals.aai.org
Graft-versus-host disease (GVHD) is a complication of allogeneic bone marrow
transplantation whereby transplanted naive and marrow-derived T cells damage recipient …

The role of extracorporeal photopheresis in the management of cutaneous T‐cell lymphoma, graft‐versus‐host disease and organ transplant rejection: a consensus …

A Alfred, PC Taylor, F Dignan… - British journal of …, 2017 - Wiley Online Library
Extracorporeal photopheresis (ECP) has been used for over 35 years in the treatment of
erythrodermic cutaneous T‐cell lymphoma (CTCL) and over 20 years for chronic and acute …

Chronic graft-versus-host disease detected by tissue-specific cell-free DNA methylation biomarkers

B Avni, D Neiman, E Shaked… - The Journal of …, 2024 - Am Soc Clin Investig
BACKGROUND. Accurate detection of graft-versus-host disease (GVHD) is a major
challenge in the management of patients undergoing hematopoietic stem cell …

[HTML][HTML] National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: III. The 2014 Biomarker Working …

S Paczesny, FT Hakim, J Pidala, KR Cooke… - Biology of blood and …, 2015 - Elsevier
Biology-based markers to confirm or aid in the diagnosis or prognosis of chronic graft-versus-
host disease (GVHD) after allogeneic hematopoietic cell transplantation or monitor its …

How ibrutinib, a B-cell malignancy drug, became an FDA-approved second-line therapy for steroid-resistant chronic GVHD

SM Jaglowski, BR Blazar - Blood advances, 2018 - ashpublications.org
Allogeneic hematopoietic stem cell transplantation (allo-SCT) is potentially curative for a
number of hematologic conditions, both malignant and nonmalignant. However, its success …

Immune profile differences between chronic GVHD and late acute GVHD: results of the ABLE/PBMTC 1202 studies

KR Schultz, A Kariminia, B Ng… - Blood, The Journal …, 2020 - ashpublications.org
Human graft-versus-host disease (GVHD) biology beyond 3 months after hematopoietic
stem cell transplantation (HSCT) is complex. The Applied Biomarker in Late Effects of …

Biomarkers in chronic graft-versus-host disease: quo vadis?

D Wolff, H Greinix, SJ Lee, T Gooley… - Bone marrow …, 2018 - nature.com
Biomarkers are increasingly used for diagnosis and treatment of transplant-related
complications including the first biomarker-driven interventional trials of acute graft-versus …

[HTML][HTML] Tear cytokines as biomarkers for chronic graft-versus-host disease

JW Jung, SJ Han, MK Song, EK Kim, YH Min… - Biology of Blood and …, 2015 - Elsevier
We investigated the tear cytokine profiles in patients who underwent stem cell
transplantation (SCT) and attempted to evaluate whether tear cytokines are associated with …