Articular cartilage injuries and degenerative joint diseases are responsible for progressive
pain and disability in millions of people worldwide, yet there is currently no treatment …

▪ Abstract Recent studies suggest that there are multiple regulatory pathways by which
chondrocytes in articular cartilage sense and respond to mechanical stimuli, including …

Solid stress and tissue stiffness affect tumour growth, invasion, metastasis and treatment.
Unlike stiffness, which can be precisely mapped in tumours, the measurement of solid …

The compression of brain tissue by a tumour mass is believed to be a major cause of the
clinical symptoms seen in patients with brain cancer. However, the biological consequences …

Due to its avascular nature, articular cartilage exhibits a very limited capacity to regenerate
and to repair. Although much of the tissue-engineered cartilage in existence has been …

The response of healthy and diseased cartilage of the knee to the mechanics of walking is
examined, with the goal of providing insight into the relationship between the kinematics and …

The composition and organisation of the extracellular matrix (ECM), particularly the
pericellular matrix (PCM), in articular cartilage is critical to its biomechanical functionality; the …

This review examines a mechanism for the initiation of osteoarthritis after anterior cruciate
ligament (ACL) injury by considering the relationship between reported ambulatory changes …

Joints are functional units that transmit mechanical loads between contacting bones during
normal daily or specialized activities, eg, sports. All components of the joint, ie articular …

Articular cartilage is a living material composed of a relatively small number of cells known
as chondrocytes surrounded by a multicomponent matrix. Mechanically, articular cartilage is …