[HTML][HTML] Oxidative stress in cancer cell metabolism
S Arfin, NK Jha, SK Jha, KK Kesari, J Ruokolainen… - Antioxidants, 2021 - mdpi.com
Reactive oxygen species (ROS) are important in regulating normal cellular processes
whereas deregulated ROS leads to the development of a diseased state in humans …
whereas deregulated ROS leads to the development of a diseased state in humans …
Understanding of ROS‐inducing strategy in anticancer therapy
SJ Kim, HS Kim, YR Seo - Oxidative medicine and cellular …, 2019 - Wiley Online Library
Redox homeostasis is essential for the maintenance of diverse cellular processes. Cancer
cells have higher levels of reactive oxygen species (ROS) than normal cells as a result of …
cells have higher levels of reactive oxygen species (ROS) than normal cells as a result of …
[HTML][HTML] Diminished efficacy of programmed death-(ligand) 1 inhibition in STK11-and KEAP1-mutant lung adenocarcinoma is affected by KRAS mutation status
Introduction STK11 and KEAP1 mutations (STK11 mutant [STK11 MUT] and KEAP1 MUT)
are among the most often mutated genes in lung adenocarcinoma (LUAD). Although STK11 …
are among the most often mutated genes in lung adenocarcinoma (LUAD). Although STK11 …
ROS signalling in the biology of cancer
JN Moloney, TG Cotter - Seminars in cell & developmental biology, 2018 - Elsevier
Increased reactive oxygen species (ROS) production has been detected in various cancers
and has been shown to have several roles, for example, they can activate pro-tumourigenic …
and has been shown to have several roles, for example, they can activate pro-tumourigenic …
ROS in cancer: the burning question
IIC Chio, DA Tuveson - Trends in molecular medicine, 2017 - cell.com
An unanswered question in human health is whether antioxidation prevents or promotes
cancer. Antioxidation has historically been viewed as chemopreventive, but emerging …
cancer. Antioxidation has historically been viewed as chemopreventive, but emerging …
[HTML][HTML] An update of Nrf2 activators and inhibitors in cancer prevention/promotion
F Pouremamali, A Pouremamali, M Dadashpour… - Cell Communication and …, 2022 - Springer
Abstract NF-E2-related factor 2 (Nrf2) protein is a basic-region leucine zipper transcription
factor that defends against endogenous or exogenous stressors. By inducing several …
factor that defends against endogenous or exogenous stressors. By inducing several …
The two faces of reactive oxygen species in cancer
CR Reczek, NS Chandel - Annual review of cancer biology, 2017 - annualreviews.org
Reactive oxygen species (ROS), now appreciated for their cellular signaling capabilities,
have a dual role in cancer. On the one hand, ROS can promote protumorigenic signaling …
have a dual role in cancer. On the one hand, ROS can promote protumorigenic signaling …
Paradoxical roles of antioxidant enzymes: basic mechanisms and health implications
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from
aerobic metabolism, as a result of accidental electron leakage as well as regulated …
aerobic metabolism, as a result of accidental electron leakage as well as regulated …
[HTML][HTML] Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells
X Liu, P Zhao, X Wang, L Wang, Y Zhu, Y Song… - Journal of Experimental …, 2019 - Springer
Background Celastrol, a triterpene compound derived from the traditional Chinese medicine
Tripterygium wilfordii, has been reported to possess potential antitumor activity towards …
Tripterygium wilfordii, has been reported to possess potential antitumor activity towards …
An overview of chemical inhibitors of the Nrf2-ARE signaling pathway and their potential applications in cancer therapy
The Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor regulating a
wide array of genes for antioxidant and detoxification enzymes in response to oxidative and …
wide array of genes for antioxidant and detoxification enzymes in response to oxidative and …