Amyotrophic lateral sclerosis is a fatal CNS neurodegenerative disease. Despite intensive
research, current management of amyotrophic lateral sclerosis remains suboptimal from …

Amyotrophic lateral sclerosis is a fatal neurodegenerative disease. The discovery of genes
associated with amyotrophic lateral sclerosis, commencing with SOD1 in 1993, started fairly …

In preclinical studies rapamycin was found to target neuroinflammation, by expanding
regulatory T cells, and affecting autophagy, two pillars of amyotrophic lateral sclerosis (ALS) …

The prevailing motor neuron-centric view of amyotrophic lateral sclerosis (ALS)
pathogenesis could be an important factor in the failure to identify disease-modifying therapy …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are
neurodegenerative diseases that overlap in their clinical presentation, pathology and …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, involving
neuroinflammation and T cell infiltration in the central nervous system. However, the …

Objective: To assess masitinib in the treatment of ALS. Methods: Double-blind study,
randomly assigning 394 patients (1: 1: 1) to receive riluzole (100 mg/d) plus placebo or …

In amyotrophic lateral sclerosis (ALS), immune cells and glia contribute to motor neuron
(MN) degeneration. We report the presence of NK cells in post-mortem ALS motor cortex …

Mesenchymal stromal cells are multipotent cells that are being used to treat a variety of
medical conditions. Over the past decade, there has been considerable excitement about …

Amyotrophic lateral sclerosis (ALS), a devastating motor neuron disease involving complex
genetic and environmental factors, is associated with neuroinflammation. Preclinical and …