Fuchs endothelial corneal dystrophy (FECD) is a common cause for heritable visual loss in
the elderly. Since the first description of an association between FECD and common …

Deficiency and dysfunction of corneal cells leads to the blindness observed in corneal
diseases such as limbal stem cell deficiency (LSCD) and bullous keratopathy. Regenerative …

Approximately one-third of childhood blindness is attributed to developmental eye disorders,
of which 80% have a genetic cause. Eye morphogenesis is tightly regulated by a highly …

Purpose: To elucidate the molecular events in solute carrier family 4 member 11 (SLC4A11)-
deficient corneal endothelium that lead to the endothelial dysfunction that characterizes the …

Animal models have provided many insights into ocular development and disease, but they
remain suboptimal for understanding human oculogenesis. Eye development requires …

The genetic architecture of corneal endothelial dystrophies remains unknown in a
substantial number of affected individuals. The proband investigated in the current study …

The cornea, the eye's outermost layer, protects the eye from the environment. The cornea's
innermost layer is an endothelium separating the stromal layer from the aqueous humor. A …

The corneal endothelium is the innermost monolayer of the cornea that maintains corneal
transparency and thickness. However, adult human corneal endothelial cells (CECs) …

Failure of corneal endothelium cell monolayer is the main cause leading to corneal
transplantation. Autologous cell-based therapies are required to reconstruct in vitro the cell …

The corneal endothelium (CE) is vital for the cornea to maintain its transparency. However,
CE dysfunction occurs due to aging, intraocular surgery, trauma, dystrophy, etc. Corneal …