Clinicians can encounter sex and gender disparities in diagnostic and therapeutic
responses. These disparities are noted in epidemiology, pathophysiology, clinical …

X-chromosome inactivation (XCI) is the epigenetic mechanism that ensures X-linked dosage
compensation between cells of females (XX karyotype) and males (XY). XCI is essential for …

Sex bias exists in the development and progression of nonreproductive organ cancers, but
the underlying mechanisms are enigmatic. Studies so far have focused largely on sexual …

Burkitt lymphoma (BL) is an aggressive form of B cell lymphoma that can affect children and
adults. The study of BL led to the identification of the first recurrent chromosomal aberration …

Curing cancer through precision medicine is the paramount aim of the new wave of
molecular and genomic therapies. Currently, whether patients with non-reproductive …

The extent of somatic mutation and clonal selection in the human bladder remains unknown.
We sequenced 2097 bladder microbiopsies from 20 individuals using targeted (n= 1914 …

UTX (also known as KDM6A) encodes a histone H3K27 demethylase and is an important
tumour suppressor that is frequently mutated in human cancers. However, as the …

The X chromosome and X-linked variants have largely been ignored in genome-wide and
candidate association studies of infectious diseases due to the complexity of statistical …

We now know that cancer is many different diseases, with great variation even within a
single histological subtype. With the current emphasis on developing personalized …

Lysine-specific demethylase 6A (KDM6A), also named UTX, is frequently mutated in bladder
cancer (BCa). Although known as a tumor suppressor, KDM6A's therapeutic potential in the …