Circadian rhythm dysregulation and restoration: the role of melatonin

C Vasey, J McBride, K Penta - Nutrients, 2021 - mdpi.com
Sleep is an essential component of overall human health but is so tightly regulated that
when disrupted can cause or worsen certain ailments. An important part of this process is …

Individual differences in light sensitivity affect sleep and circadian rhythms

SL Chellappa - Sleep, 2021 - academic.oup.com
Artificial lighting is omnipresent in contemporary society with disruptive consequences for
human sleep and circadian rhythms because of overexposure to light, particularly in the …

High sensitivity and interindividual variability in the response of the human circadian system to evening light

AJK Phillips, P Vidafar, AC Burns… - Proceedings of the …, 2019 - National Acad Sciences
Before the invention of electric lighting, humans were primarily exposed to intense (> 300
lux) or dim (< 30 lux) environmental light—stimuli at extreme ends of the circadian system's …

The role of daylight for humans: gaps in current knowledge

M Münch, A Wirz-Justice, SA Brown, T Kantermann… - Clocks & sleep, 2020 - mdpi.com
Daylight stems solely from direct, scattered and reflected sunlight, and undergoes dynamic
changes in irradiance and spectral power composition due to latitude, time of day, time of …

Evening home lighting adversely impacts the circadian system and sleep

SW Cain, EM McGlashan, P Vidafar, J Mustafovska… - Scientific reports, 2020 - nature.com
The regular rise and fall of the sun resulted in the development of 24-h rhythms in virtually all
organisms. In an evolutionary heartbeat, humans have taken control of their light …

The dim light melatonin onset across ages, methodologies, and sex and its relationship with morningness/eveningness

DJ Kennaway - Sleep, 2023 - academic.oup.com
The onset of melatonin secretion, the dim light melatonin onset (DLMO), is a tool for
determining the phase of the circadian timing system. Although small studies have …

The evening light environment in hospitals can be designed to produce less disruptive effects on the circadian system and improve sleep

D Vethe, J Scott, M Engstrøm, Ø Salvesen, T Sand… - Sleep, 2021 - academic.oup.com
Abstract Study Objectives Blue-depleted lighting reduces the disruptive effects of evening
artificial light on the circadian system in laboratory experiments, but this has not yet been …

Sleep physiology, circadian rhythms, waking performance and the development of sleep-wake therapeutics

DJ Dijk, HP Landolt - Sleep-wake neurobiology and pharmacology, 2019 - Springer
Disturbances of the sleep-wake cycle are highly prevalent and diverse. The aetiology of
some sleep disorders, such as circadian rhythm sleep-wake disorders, is understood at the …

Workshop report. Circadian rhythm sleep–wake disorders: gaps and opportunities

JF Duffy, SM Abbott, HJ Burgess, SJ Crowley… - Sleep, 2021 - academic.oup.com
Abstract This White Paper presents the results from a workshop cosponsored by the Sleep
Research Society (SRS) and the Society for Research on Biological Rhythms (SRBR) …

Timing is everything: Circadian rhythms and their role in the control of sleep

SR Pandi-Perumal, DP Cardinali, NFW Zaki… - Frontiers in …, 2022 - Elsevier
Sleep and the circadian clock are intertwined and have persisted throughout history. The
suprachiasmatic nucleus (SCN) orchestrates sleep by controlling circadian (Process C) and …