[HTML][HTML] Early detection of pancreatic cancer: opportunities and challenges

AD Singhi, EJ Koay, ST Chari, A Maitra - Gastroenterology, 2019 - Elsevier
Most patients with pancreatic ductal adenocarcinoma (PDAC) present with symptomatic,
surgically unresectable disease. Although the goal of early detection of PDAC is laudable …

Preoperative chemotherapy, radiotherapy and surgical decision-making in patients with borderline resectable and locally advanced pancreatic cancer

TF Stoop, RT Theijse, LWF Seelen… - Nature Reviews …, 2024 - nature.com
Surgical resection combined with systemic chemotherapy is the cornerstone of treatment for
patients with localized pancreatic cancer. Upfront surgery is considered suboptimal in cases …

Tumor-derived IL-6 and trans-signaling among tumor, fat, and muscle mediate pancreatic cancer cachexia

JE Rupert, A Narasimhan, DHA Jengelley… - Journal of Experimental …, 2021 - rupress.org
Most patients with pancreatic adenocarcinoma (PDAC) suffer cachexia; some do not. To
model heterogeneity, we used patient-derived orthotopic xenografts. These phenocopied …

Nutritional support and therapy in pancreatic surgery: A position paper of the International Study Group on Pancreatic Surgery (ISGPS)

L Gianotti, MG Besselink, M Sandini, T Hackert… - Surgery, 2018 - Elsevier
Background The optimal nutritional therapy in the field of pancreatic surgery is still debated.
Methods An international panel of recognized pancreatic surgeons and pancreatologists …

Effects of weight loss and sarcopenia on response to chemotherapy, quality of life, and survival

AM Ryan, CM Prado, ES Sullivan, DG Power, LE Daly - Nutrition, 2019 - Elsevier
It has frequently been shown that patients with cancer are one of the largest hospital patient
groups with a prevalence for malnutrition. Weight loss is a frequent manifestation of …

Sarcopenia and obesity

M Zamboni, S Rubele, AP Rossi - Current Opinion in Clinical …, 2019 - journals.lww.com
Further research is needed to compare different definitions of sarcopenic/dynapenic obesity
to clarify the relationship between obesity and the most important adverse outcomes in the …

Chemotherapy-induced sarcopenia

F Bozzetti - Current treatment options in oncology, 2020 - Springer
Opinion statement Sarcopenia is being consistently recognized as a condition not only
associated with the presence of a malignancy but also induced by the oncologic therapies …

Prehabilitation prior to surgery for pancreatic cancer: a systematic review

JR Bundred, SK Kamarajah, JS Hammond, CH Wilson… - Pancreatology, 2020 - Elsevier
Introduction Prehabilitation aims to improve fitness and outcomes of patients undergoing
major surgery. This systematic review aimed to appraise current available evidence …

Preservation of muscle mass as a strategy to reduce the toxic effects of cancer chemotherapy on body composition

F Pin, ME Couch, A Bonetto - Current opinion in supportive and …, 2018 - journals.lww.com
Muscle wasting often occurs as a consequence of anticancer treatments and is indicative of
worse outcomes and poor quality of life in cancer patients. Accurate assessment of body …

[HTML][HTML] Body composition assessment and sarcopenia in patients with pancreatic cancer: a systematic review and meta-analysis

J Bundred, SK Kamarajah, KJ Roberts - HPB, 2019 - Elsevier
Background Numerous studies have suggested an association between sarcopenia in
pancreatic cancer and adverse outcomes. This systematic review examines the evidence for …