COVID-19 convalescent plasma and clinical trials: understanding conflicting outcomes

D Focosi, M Franchini, L Pirofski… - Clinical microbiology …, 2022 - Am Soc Microbiol
Convalescent plasma (CP) recurs as a frontline treatment in epidemics because it is
available as soon as there are survivors. The COVID-19 pandemic represented the first …

Antibody and cellular therapies for treatment of covid-19: a living systematic review and network meta-analysis

RAC Siemieniuk, JJ Bartoszko, JPD Martinez, E Kum… - Bmj, 2021 - bmj.com
Objective To evaluate the efficacy and safety of antiviral antibody therapies and blood
products for the treatment of novel coronavirus disease 2019 (covid-19). Design Living …

Infectious Diseases Society of America Guidelines on the treatment and management of patients with coronavirus disease 2019 (COVID-19)

A Bhimraj, RL Morgan, AH Shumaker… - Clinical Infectious …, 2020 - academic.oup.com
Background There are many pharmacologic therapies that are being used or considered for
treatment of coronavirus disease 2019 (COVID-19). There is a need for frequently updated …

A multicenter randomized open-label clinical trial for convalescent plasma in patients hospitalized with COVID-19 pneumonia

C Avendaño-Solá, A Ramos-Martínez… - The Journal of …, 2021 - Am Soc Clin Investig
BACKGROUND Passive immunotherapy with convalescent plasma (CP) is a potential
treatment for COVID-19. Evidence from controlled clinical trials is inconclusive. METHODS …

High-titre methylene blue-treated convalescent plasma as an early treatment for outpatients with COVID-19: a randomised, placebo-controlled trial

A Alemany, P Millat-Martinez… - The Lancet …, 2022 - thelancet.com
Background Convalescent plasma has been proposed as an early treatment to interrupt the
progression of early COVID-19 to severe disease, but there is little definitive evidence. We …

Coronavirus disease 2019 as cause of viral sepsis: a systematic review and meta-analysis

E Karakike, EJ Giamarellos-Bourboulis… - Critical care …, 2021 - journals.lww.com
Objective: Coronavirus disease 2019 is a heterogeneous disease most frequently causing
respiratory tract infection, which can induce respiratory failure and multiple organ …

Results of the CAPSID randomized trial for high-dose convalescent plasma in patients with severe COVID-19

S Körper, M Weiss, D Zickler… - The Journal of …, 2021 - Am Soc Clin Investig
BACKGROUND COVID-19 convalescent plasma (CCP) has been considered a treatment
option for COVID-19. This trial assessed the efficacy of a neutralizing antibody containing …

Effect of high-titer convalescent plasma on progression to severe respiratory failure or death in hospitalized patients with COVID-19 pneumonia: a randomized clinical …

F Menichetti, P Popoli, M Puopolo… - JAMA network …, 2021 - jamanetwork.com
Importance Convalescent plasma (CP) has been generally unsuccessful in preventing
worsening of respiratory failure or death in hospitalized patients with COVID-19 pneumonia …

[HTML][HTML] Rates among hospitalized patients with COVID-19 treated with convalescent plasma: a systematic review and meta-analysis

JW Senefeld, EK Gorman, PW Johnson, ME Moir… - … : Innovations, Quality & …, 2023 - Elsevier
Objective To examine the association of COVID-19 convalescent plasma transfusion with
mortality and the differences between subgroups in hospitalized patients with COVID-19 …

A phase 2 single center open label randomised control trial for convalescent plasma therapy in patients with severe COVID-19

Y Ray, SR Paul, P Bandopadhyay, R D'Rozario… - Nature …, 2022 - nature.com
A single center open label phase 2 randomised control trial (Clinical Trial Registry of India
No. CTRI/2020/05/025209) was done to assess clinical and immunological benefits of …