Excitotoxicity is a phenomenon that describes the toxic actions of excitatory
neurotransmitters, primarily glutamate, where the exacerbated or prolonged activation of …

Brain tissue has a remarkable ability to accumulate glutamate. This ability is due to
glutamate transporter proteins present in the plasma membranes of both glial cells and …

Neurons are often considered to be the computational engines of the brain, with synapses
acting solely as conveyers of information. But the diverse types of synaptic plasticity and the …

Several lines of evidence indicate that brief (< 25 ms) bursts of high-frequency firing have
special importance in brain function. Recent work shows that many central synapses are …

The peak concentration and rate of clearance of neurotransmitter from the synaptic cleft are
important determinants of synaptic function, yet the neurotransmitter concentration time …

The vast computational power of the brain has traditionally been viewed as arising from the
complex connectivity of neural networks, in which an individual neuron acts as a simple …

SYNAPTIC transmission is commonly terminated by diffusion and reuptake of
neurotransmitter from the synaptic cleft. Glutamate reuptake prevents neurotoxicity and sets …

Glutamate receptors (GluRs) mediate most of the excitatory neurotransmission in the
mammalian central nervous system (CNS). In addition, they are involved in plastic changes …

Dendrites are the main recipients of synaptic inputs and are important sites that determine
neurons' input-output functions. This review focuses on thin neocortical dendrites, which …

Functionally diverse GluR channels of the AMPA subtype are generated by the assembly of
CIuR-A,-B,-C, and-D subunits into home-and heteromeric channels. The CIuR-B subunit is …