Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials
EE Patton, LI Zon, DM Langenau - Nature Reviews Drug Discovery, 2021 - nature.com
Numerous drug treatments that have recently entered the clinic or clinical trials have their
genesis in zebrafish. Zebrafish are well established for their contribution to developmental …
genesis in zebrafish. Zebrafish are well established for their contribution to developmental …
Single-cell RNA sequencing for the study of development, physiology and disease
SS Potter - Nature Reviews Nephrology, 2018 - nature.com
An ongoing technological revolution is continually improving our ability to carry out very high-
resolution studies of gene expression patterns. Current technology enables the global gene …
resolution studies of gene expression patterns. Current technology enables the global gene …
Zebrafish information network, the knowledgebase for Danio rerio research
YM Bradford, CE Van Slyke, L Ruzicka, A Singer… - Genetics, 2022 - academic.oup.com
Abstract The Zebrafish Information Network (zfin. org) is the central repository for Danio rerio
genetic and genomic data. The Zebrafish Information Network has served the zebrafish …
genetic and genomic data. The Zebrafish Information Network has served the zebrafish …
[HTML][HTML] Single-cell transcriptomics meets lineage tracing
L Kester, A Van Oudenaarden - Cell stem cell, 2018 - cell.com
Reconstructing lineage relationships between cells within a tissue or organism is a long-
standing aim in biology. Traditionally, lineage tracing has been achieved through the …
standing aim in biology. Traditionally, lineage tracing has been achieved through the …
[HTML][HTML] Single-cell trajectories reconstruction, exploration and mapping of omics data with STREAM
Single-cell transcriptomic assays have enabled the de novo reconstruction of lineage
differentiation trajectories, along with the characterization of cellular heterogeneity and state …
differentiation trajectories, along with the characterization of cellular heterogeneity and state …
Zebrafish patient avatars in cancer biology and precision cancer therapy
In precision oncology, two major strategies are being pursued for predicting clinically
relevant tumour behaviours, such as treatment response and emergence of drug resistance …
relevant tumour behaviours, such as treatment response and emergence of drug resistance …
[HTML][HTML] A single-cell transcriptome atlas for zebrafish development
The ability to define cell types and how they change during organogenesis is central to our
understanding of animal development and human disease. Despite the crucial nature of this …
understanding of animal development and human disease. Despite the crucial nature of this …
[HTML][HTML] Visualizing engrafted human cancer and therapy responses in immunodeficient zebrafish
Xenograft cell transplantation into immunodeficient mice has become the gold standard for
assessing pre-clinical efficacy of cancer drugs, yet direct visualization of single-cell …
assessing pre-clinical efficacy of cancer drugs, yet direct visualization of single-cell …
Proteomic analysis of single mammalian cells enabled by microfluidic nanodroplet sample preparation and ultrasensitive NanoLC‐MS
We report on the quantitative proteomic analysis of single mammalian cells. Fluorescence‐
activated cell sorting was employed to deposit cells into a newly developed nanodroplet …
activated cell sorting was employed to deposit cells into a newly developed nanodroplet …
Hematopoietic hierarchy–an updated roadmap
The classical roadmap of hematopoietic hierarchy has been proposed for nearly 20 years
and has become a dogma of stem cell research for most types of adult stem cells, including …
and has become a dogma of stem cell research for most types of adult stem cells, including …