The pharmacology and clinical efficacy of antiseizure medications: from bromide salts to cenobamate and beyond
Epilepsy is one of the most common and disabling chronic neurological disorders.
Antiseizure medications (ASMs), previously referred to as anticonvulsant or antiepileptic …
Antiseizure medications (ASMs), previously referred to as anticonvulsant or antiepileptic …
The pharmacoresistant epilepsy: an overview on existant and new emerging therapies
A Fattorusso, S Matricardi, E Mencaroni… - Frontiers in …, 2021 - frontiersin.org
Epilepsy is one of the most common neurological chronic disorders, with an estimated
prevalence of 0. 5–1%. Currently, treatment options for epilepsy are predominantly based on …
prevalence of 0. 5–1%. Currently, treatment options for epilepsy are predominantly based on …
International consensus on diagnosis and management of Dravet syndrome
EC Wirrell, V Hood, KG Knupp, MA Meskis… - …, 2022 - Wiley Online Library
Objective This study was undertaken to gain consensus from experienced physicians and
caregivers regarding optimal diagnosis and management of Dravet syndrome (DS), in the …
caregivers regarding optimal diagnosis and management of Dravet syndrome (DS), in the …
Precision medicine for genetic epilepsy on the horizon: Recent advances, present challenges, and suggestions for continued progress
JK Knowles, I Helbig, CS Metcalf, LS Lubbers… - …, 2022 - Wiley Online Library
The genetic basis of many epilepsies is increasingly understood, giving rise to the possibility
of precision treatments tailored to specific genetic etiologies. Despite this, current medical …
of precision treatments tailored to specific genetic etiologies. Despite this, current medical …
Psychobehavioural and cognitive adverse events of anti-seizure medications for the treatment of developmental and epileptic encephalopathies
A Strzelczyk, S Schubert-Bast - CNS drugs, 2022 - Springer
The developmental and epileptic encephalopathies encompass a group of rare syndromes
characterised by severe drug-resistant epilepsy with onset in childhood and significant …
characterised by severe drug-resistant epilepsy with onset in childhood and significant …
Efficacy and safety of fenfluramine for the treatment of seizures associated with Lennox-Gastaut syndrome: a randomized clinical trial
KG Knupp, IE Scheffer, B Ceulemans… - JAMA …, 2022 - jamanetwork.com
Importance New treatment options are needed for patients with Lennox-Gastaut syndrome
(LGS), a profoundly impairing, treatment-resistant, developmental and epileptic …
(LGS), a profoundly impairing, treatment-resistant, developmental and epileptic …
Developmental and epileptic encephalopathies: what we do and do not know
N Specchio, P Curatolo - Brain, 2021 - academic.oup.com
Developmental encephalopathies, including intellectual disability and autistic spectrum
disorder, are frequently associated with infant epilepsy. Epileptic encephalopathy is used to …
disorder, are frequently associated with infant epilepsy. Epileptic encephalopathy is used to …
New epilepsy therapies in development
Epilepsy is a common brain disorder, characterized by spontaneous recurrent seizures, with
associated neuropsychiatric and cognitive comorbidities and increased mortality. Although …
associated neuropsychiatric and cognitive comorbidities and increased mortality. Although …
A practical guide to the treatment of Dravet syndrome with anti-seizure medication
A Strzelczyk, S Schubert-Bast - CNS drugs, 2022 - Springer
Dravet syndrome is a severe developmental and epileptic encephalopathy characterised by
refractory seizures and cognitive dysfunction. The treatment is challenging, not least …
refractory seizures and cognitive dysfunction. The treatment is challenging, not least …
Developmental and epileptic encephalopathies
Developmental and epileptic encephalopathies, the most severe group of epilepsies, are
characterized by seizures and frequent epileptiform activity associated with developmental …
characterized by seizures and frequent epileptiform activity associated with developmental …