Molecular stratification using gene-level transcriptional data has identified subtypes with
distinctive genotypic and phenotypic traits, as exemplified by the consensus molecular …

Metastasized colorectal cancer (CRC) is associated with a poor prognosis and rapid
disease progression. Besides hepatic metastasis, peritoneal carcinomatosis is the major …

Despite extensive research and improvements in understanding colorectal cancer (CRC), its
metastatic form continues to pose a substantial challenge, primarily owing to limited …

Over the past decade, our understanding of the diversity of colorectal cancer has expanded
significantly, raising hopes of tailoring treatments more precisely for individual patients. A …

BRAF mutations occur early in serrated colorectal cancers, but their long-term influence on
tissue homeostasis is poorly characterized. We investigated the impact of short-term (3 days) …

Intra-tumor heterogeneity compromises the clinical value of transcriptomic classifications of
colorectal cancer. We investigated the prognostic effect of transcriptomic heterogeneity and …

Purpose: The current approach for molecular subtyping of colon cancer relies on gene
expression profiling, which is invasive and has limited ability to reveal dynamics and spatial …

Gastrointestinal (GI) cancers are highly heterogeneous at multiple levels. Tumor
heterogeneity can be captured by molecular profiling, such as genetic, epigenetic …

Colorectal cancer (CRC) is the third most prevalent cancer worldwide with a high mortality
rate (20–30%), especially due to metastasis to adjacent organs. Clinical responses to …

Despite the abundance of macrophages in colorectal cancer (CRC), macrophage-targeted
therapy has not demonstrated significant clinical benefit. Here, we show that macrophage …