Protein and phosphoinositide kinases have been successfully exploited as drug targets in
various disease areas, principally in oncology. In malaria, several protein kinases are under …

The molecular pharmacology of artemisinin (ART)-based antimalarial drugs is incompletely
understood. Clinically, these drugs are used in combination with longer lasting partner drugs …

Drug resistance in Plasmodium parasites is a constant threat. Novel therapeutics, especially
new drug combinations, must be identified at a faster rate. In response to the urgent need for …

A regulated protein turnover machinery in the cell is essential for effective cellular
homeostasis; any interference with this system induces cellular stress and alters the normal …

Malaria is a parasitic disease (caused by different Plasmodium species) that affects millions
of people worldwide. The lack of effective malaria drugs and a vaccine contributes to this …

In apicomplexan parasites, the macroautophagy/autophagy machinery is repurposed to
maintain the plastid-like organelle apicoplast. Previously, we showed that in Toxoplasma …

Emerging resistance to artemisinin (ART) has become a challenge for reducing worldwide
malaria mortality and morbidity. The C580Y mutation in Plasmodium falciparum Kelch13 has …

Atg8 is a ubiquitin-like autophagy protein in eukaryotes that is covalently attached (lipidated)
to the elongating autophagosomal membrane. Autophagy is increasingly appreciated as a …

The precise role of autophagy in P. falciparum remains largely unknown. Although a limited
number of autophagy genes have been identified in this apicomplexan, only Pf Atg8 has …

In 1918, quinine was used as one of the unscientifically based treatments against the H1N1
virus during the Spanish flu pandemic. Originally, quinine was extracted from the bark of …