Microbial consortia have been used in biotechnology processes, including fermentation,
waste treatment, and agriculture, for millennia. Today, synthetic biologists are increasingly …

Metabolic engineers endeavor to create a bio-based manufacturing industry using microbes
to produce fuels, chemicals, and medicines. Plant natural products (PNPs) are historically …

Alkaloids from plants are characterised by structural diversity and bioactivity, and maintain a
privileged position in both modern and traditional medicines. In recent years, there have …

Recent developments in synthetic biology, combined with continued progress in systems
biology and metabolic engineering, have enabled the engineering of microorganisms to …

Metabolic engineering of microorganisms such as Escherichia coli and Saccharomyces
cerevisiae to produce high-value natural metabolites is often done through functional …

The monoterpene indole alkaloids are a large group of plant-derived specialized
metabolites, many of which have valuable pharmaceutical or biological activity. There are∼ …

The microbial production of fine chemicals provides a promising biosustainable
manufacturing solution that has led to the successful production of a growing catalog of …

Metabolic pathways are often engineered in single microbial populations. However, the
introduction of heterologous circuits into the host can create a substantial metabolic burden …

The ability to site-selectively modify equivalent functional groups in a molecule has the
potential to streamline syntheses and increase product yields by lowering step counts …

Benzylisoquinoline alkaloids (BIAs) are a diverse family of plant-specialized metabolites that
include the pharmaceuticals codeine and morphine and their derivatives. Microbial …