The lymphatic system is comprised of a network of vessels interrelated with lymphoid tissue,
which has the holistic function to maintain the local physiologic environment for every cell in …

Mucin type O‐glycosylation is one of the most diverse types of glycosylation, playing
essential roles in tissue development and homeostasis. In complex organisms, O‐GalNAc …

Aberrant glycosylation plays a fundamental role in key pathological steps of tumour
development and progression. Glycans have roles in cancer cell signalling, tumour cell …

Podoplanin is a small cell-surface mucin-like glycoprotein that plays a crucial role in the
development of the alveoli, heart, and lymphatic vascular system. Emerging evidence …

Angiogenesis and lymphangiogenesis often occur in response to tissue injury or in the
presence of pathology (eg, cancer), and it is these types of environments in which …

The clinical benefit conferred by vascular endothelial growth factors (VEGF)-targeted
therapies is variable, and tumors from treated patients eventually reinitiate growth. Here, we …

Spleen tyrosine kinase (SYK) is known to have a crucial role in adaptive immune receptor
signalling. However, recent reports indicate that SYK also mediates other, unexpectedly …

The growth of lymphatic vessels (lymphangiogenesis) is actively involved in a number of
pathological processes including tissue inflammation and tumor dissemination but is …

Podoplanin (PDPN) is a well-conserved, mucin-type transmembrane protein expressed in
multiple tissues during ontogeny and in adult animals, including the brain, heart, kidney …

The lymphatic vasculature constitutes a highly specialized part of the vascular system that is
essential for the maintenance of interstitial fluid balance, uptake of dietary fat, and immune …