Ferroptosis is a novel type of programmed cell death, characterized by a dysregulated iron
metabolism and accumulation of lipid peroxides. It features the alteration of mitochondria …

Dysregulation of metabolism is a common phenomenon in cancer cells. The NADP+-
dependent isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) function at a crossroads of …

Glioblastoma multiforme (GBM) is the most common and lethal type of brain cancer. To
identify the genetic alterations in GBMs, we sequenced 20,661 protein coding genes …

Purpose To analyze the frequency and prognostic impact of isocitrate dehydrogenase 1
(IDH1) and isocitrate dehydrogenase 2 (IDH2) mutations in acute myeloid leukemia (AML) …

Isocitrate dehydrogenases (IDHs) catalyze the oxidative decarboxylation of isocitrate to α-
ketoglutarate, and regulation of the enzymatic activity of IDHs is crucial for their biological …

NADPH is an important cofactor in many biosynthesis pathways and the regeneration of
reduced glutathione, critically important in cellular defense against oxidative damage. It is …

The two iron regulatory proteins IRP1 and IRP2 bind to transcripts of ferritin, transferrin
receptor and other target genes to control the expression of iron metabolism proteins at the …

The liver is a major store of glycogen and is essential in maintaining systemic glucose
homeostasis. In healthy individuals, glycogen synthesis and breakdown in the liver are …

Ammonium is the reduced nitrogen form available to plants for assimilation into amino acids.
This is achieved by the GS/GOGAT pathway that requires carbon skeletons in the form of 2 …

Epigenetic alterations are associated with all aspects of cancer, from tumor initiation to
cancer progression and metastasis. It is now well understood that both losses and gains of …