Emerging imaging spatial transcriptomics (iST) platforms and coupled analytical methods
can recover cell-to-cell interactions, groups of spatially covarying genes, and gene …

Although distinct epithelial cell types have been distinguished in glandular tissues such as
the mammary gland, the extent of heterogeneity within each cell type and the degree of …

Genome-wide association studies have identified more than 220 loci associated with breast
cancer susceptibility. A major challenge is now to identify the effector genes with plausible …

During development and differentiation, transcriptional regulation in the cell often occurs at
the level of gene programs (ie, sets of co-varying genes), rather than isolated genes. It is …

Single nuclei analysis is allowing robust classification of cell types in an organ that helps to
establish relationships between cell-type specific gene expression and chromatin …

Large-scale multi-subject single-cell data have become very common. For differential gene
expression (DGE) analysis of these datasets, a common practice is to choose any of the two …