Oxidative metabolism as a cause of lipid peroxidation in the execution of ferroptosis

J Fujii, H Imai - International Journal of Molecular Sciences, 2024 - pmc.ncbi.nlm.nih.gov
Ferroptosis is a type of nonapoptotic cell death that is characteristically caused by
phospholipid peroxidation promoted by radical reactions involving iron. Researchers have …

Ferroptosis as a new tool for tumor suppression through lipid peroxidation

X Yang, Y Liu, Z Wang, Y Jin, W Gu - Communications Biology, 2024 - nature.com
As a newly defined type of programmed cell death, ferroptosis is considered a potent
weapon against tumors due to its distinct mechanism from other types of programmed cell …

Acteoside alleviates lipid peroxidation by enhancing Nrf2-mediated mitophagy to inhibit ferroptosis for neuroprotection in Parkinson's disease

Z Han, B Wang, YQ Wen, YN Li, CX Feng… - Free Radical Biology …, 2024 - Elsevier
Increasing evidence underscores the pivotal role of ferroptosis in Parkinson's Disease (PD)
pathogenesis. Acteoside (ACT) has been reported to possess neuroprotective properties …

Ferroptosis is a targetable detrimental factor in metabolic dysfunction-associated steatotic liver disease

C Peleman, S Hellemans, G Veeckmans… - Cell Death & …, 2024 - nature.com
There is an unmet clinical need for pharmacologic treatment for metabolic dysfunction-
associated steatotic liver disease (MASLD). Hepatocyte cell death is a hallmark of this highly …

Microbiota-derived lysophosphatidylcholine alleviates Alzheimer's disease pathology via suppressing ferroptosis

X Zha, X Liu, M Wei, H Huang, J Cao, S Liu, X Bian… - Cell Metabolism, 2024 - cell.com
Alzheimer's disease (AD) is a pervasive neurodegenerative disorder, and new approaches
for its prevention and therapy are critically needed. Here, we elucidate a gut-microbiome …

Synthetic vectors for activating the driving axis of ferroptosis

J Jiang, L Yang, Q Xie, X Liu, J Jiang, J Zhang… - Nature …, 2024 - nature.com
Ferroptosis is a promising strategy for cancer therapy, with numerous inhibitors of its braking
axes under investigation as potential drugs. However, few studies have explored the …

Human genetics identify convergent signals in mitochondrial LACTB-mediated lipid metabolism in cardiovascular-kidney-metabolic syndrome

S Li, H Liu, H Hu, E Ha, P Prasad, BC Jenkins, US Das… - Cell Metabolism, 2024 - cell.com
The understanding of cardiovascular-kidney-metabolic syndrome remains difficult despite
recently performed large scale genome-wide association studies. Here, we identified beta …

Ferroptosis-inducing nanomedicine and targeted short peptide for synergistic treatment of hepatocellular carcinoma

L Wang, L Tong, Z Xiong, Y Chen, P Zhang… - Journal of …, 2024 - Springer
The poor prognosis of hepatocellular carcinoma (HCC) is still an urgent challenge to be
solved worldwide. Hence, assembling drugs and targeted short peptides together to …

Ferroptosis: Mechanisms and therapeutic targets

Q Zhou, Y Meng, J Le, Y Sun, Y Dian, L Yao… - MedComm, 2024 - Wiley Online Library
Ferroptosis is a nonapoptotic form of cell death characterized by iron‐dependent lipid
peroxidation in membrane phospholipids. Since its identification in 2012, extensive research …

Exploiting ferroptosis vulnerabilities in cancer

T Nakamura, M Conrad - Nature Cell Biology, 2024 - nature.com
Ferroptosis is a distinct lipid peroxidation-dependent form of necrotic cell death. This
process has been increasingly contemplated as a new target for cancer therapy because of …