Disorders of the mesenteric, portal, and hepatic veins and mesenteric and hepatic arteries
have important clinical consequences and may lead to acute liver failure, chronic liver …

Myeloproliferative neoplasms (MPNs) originate from genetically transformed hematopoietic
stem cells that retain the capacity for multilineage differentiation and effective myelopoiesis …

The major vascular disorders of the liver are listed in Table 2. Most of the vascular disorders
of the liver are rare, with the exception of portal vein thrombosis (PVT) in patients with …

Myeloproliferative neoplasms (MPNs) are the most common cause of Budd-Chiari syndrome
(BCS) and nonmalignant, noncirrhotic portal vein thrombosis (PVT). In this meta-analysis …

Background: The Budd–Chiari syndrome (BCS) is hepatic venous outflow obstruction. What
is known about the syndrome is based on small studies of prevalent cases. Objective: To …

The Janus kinase 2 mutation, JAK2 617V> F, is myeloid neoplasm-specific; its presence
excludes secondary polycythemia, thrombocytosis, or bone marrow fibrosis from other …

The discovery of an identical mutation (V617F) of the JAK2 gene in patients with
polycythemia vera, essential thrombocythemia, and myelofibrosis—the principal …

There has been a remarkable explosion of knowledge into the molecular defects that
underlie the acute and chronic leukemias, leading to the introduction of targeted therapies …

Abstract Background Patients with Ph-negative myeloproliferative neoplasms (MPN), such
as polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis …

1Guy's and St Thomas' NHS Foundation Trust, London, 2Russells Hall Hospital, Dudley,
West Midlands, 3Arrowe Park Hospital Arrowe Park Road Upton Wirral, 4Wellcome Trust …