Melanoma is the most deadly of the common skin cancers and its incidence is rapidly
increasing. Approximately 10% of cases occur in a familial context. To date, cyclin …

Approximately 10% of melanoma cases report a relative affected with melanoma, and a
positive family history is associated with an increased risk of developing melanoma …

Nearly 15% of melanomas occur in patients with a family history and a subset of these
patients have a germline mutation in a melanoma predisposing gene. CDKN2A mutations …

Twenty years ago, the first familial melanoma susceptibility gene, CDKN 2A, was identified.
Two years later, another high‐penetrance gene, CDK 4, was found to be responsible for …

A family history of melanoma greatly increases the risk of developing cutaneous melanoma,
a highly aggressive skin cancer whose incidence has been steadily increasing worldwide …

Uveal melanoma (UM) is the most common malignant eye tumor in adults affecting~ 7,000
individuals per year worldwide. UM is a rare subtype of melanoma with distinct clinical and …

CDKN2A is cell cycle negative regulator, and the role of CDKN2A in the development of
pancreatic ductal adenocarcinoma, which continues to be a lethal cancer, is well …

There are many links between cell senescence and the genetics of melanoma, meaning
both familial susceptibility and somatic–genetic changes in sporadic melanoma. For …

Germline CDKN2A mutations occur in 40% of 3-or-more case melanoma families while
mutations of CDK4, BAP1, and genes involved in telomere function (ACD, TERF2IP, POT1) …

Background: Germline mutations in CDKN2A have been associated with increased risk of
melanoma and tobacco-related cancers in respiratory and upper digestive tissues. In …