WNT signaling is an elaborate and complex collection of signal transduction pathways
mediated by multiple signaling molecules. WNT signaling is critically important for …

Ischemic heart disease is the main cause of death worldwide and is accelerated by
increased levels of low-density lipoprotein cholesterol (LDL-C). Proprotein convertase …

After myocardial infarction (MI), the heart is difficult to repair because of great loss of
cardiomyoctyes and lack of cardiac regeneration. Novel drug candidates that aim at …

Various cell types are involved in the healing process after myocardial infarction (MI).
Besides cardiac resident cells (such as cardiomyocytes, fibroblasts and endothelial cells) …

Wnt signaling encompasses multiple and complex signaling cascades and is involved in
many developmental processes such as tissue patterning, cell fate specification, and control …

The neonatal heart can efficiently regenerate within a short period after birth, whereas the
adult mammalian heart has extremely limited capacity to regenerate. The molecular …

Polyunsaturated fatty acids (PUFAs), which cannot be synthesized by animals and must be
supplied from the diet, have been strongly associated with human health. However, the …

The overactivation of canonical Wnt/β-catenin pathway is one of the main cascades for the
initiation, progression, and recurrence of most human malignancies. As an indispensable …

Wnt/β-catenin signaling is activated in the heart after myocardial infarction (MI). This study
aims to investigate if β-catenin deletion affects post-MI ion channel gene alterations and …

Aims There is little information on the regulation of cholesterol homeostasis in the brain.
Whether cholesterol crosses the blood–brain barrier is under investigation, but the present …