Dopamine, immunity, and disease

B Channer, SM Matt, EA Nickoloff-Bybel, V Pappa… - Pharmacological …, 2023 - Elsevier
The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …

Beyond the GFAP-astrocyte protein markers in the brain

AM Jurga, M Paleczna, J Kadluczka, KZ Kuter - Biomolecules, 2021 - mdpi.com
The idea of central nervous system as one-man band favoring neurons is long gone. Now
we all are aware that neurons and neuroglia are team players and constant communication …

G-protein-coupled receptors in astrocyte–neuron communication

P Kofuji, A Araque - Neuroscience, 2021 - Elsevier
Astrocytes, a major type of glial cell, are known to play key supportive roles in brain function,
contributing to ion and neurotransmitter homeostasis, maintaining the blood–brain barrier …

Adenosine-independent regulation of the sleep–wake cycle by astrocyte activity

W Peng, X Liu, G Ma, Z Wu, Z Wang, X Fei, M Qin… - Cell discovery, 2023 - nature.com
Astrocytes play a crucial role in regulating sleep–wake behavior, and adenosine signaling is
generally thought to be involved. Here we show multiple lines of evidence supporting that …

Stress gates an astrocytic energy reservoir to impair synaptic plasticity

C Murphy-Royal, AD Johnston, AKJ Boyce… - Nature …, 2020 - nature.com
Astrocytes support the energy demands of synaptic transmission and plasticity. Enduring
changes in synaptic efficacy are highly sensitive to stress, yet whether changes to astrocyte …

Ion channels and electrophysiological properties of astrocytes: implications for emergent stimulation technologies

J McNeill, C Rudyk, ME Hildebrand… - Frontiers in Cellular …, 2021 - frontiersin.org
Astrocytes comprise a heterogeneous cell population characterized by distinct
morphologies, protein expression and function. Unlike neurons, astrocytes do not generate …

Astrocyte–neuron networks: a multilane highway of signaling for homeostatic brain function

S Mederos, C González-Arias, G Perea - Frontiers in synaptic …, 2018 - frontiersin.org
Research on glial cells over the past 30 years has confirmed the critical role of astrocytes in
pathophysiological brain states. However, most of our knowledge about astrocyte …

Strategies for the treatment of Parkinson's disease: beyond dopamine

A Iarkov, GE Barreto, JA Grizzell… - Frontiers in aging …, 2020 - frontiersin.org
Parkinson's disease (PD) is the second-leading cause of dementia and is characterized by a
progressive loss of dopaminergic neurons in the substantia nigra alongside the presence of …

Astrocytes mediate long-lasting synaptic regulation of ventral tegmental area dopamine neurons

LM Requie, M Gómez-Gonzalo, M Speggiorin… - Nature …, 2022 - nature.com
The plasticity of glutamatergic transmission in the ventral tegmental area (VTA) represents a
fundamental mechanism in the modulation of dopamine neuron burst firing and phasic …

Dopamine activates astrocytes in prefrontal cortex via α1-adrenergic receptors

S Pittolo, S Yokoyama, DD Willoughby, CR Taylor… - Cell reports, 2022 - cell.com
The prefrontal cortex (PFC) is a hub for cognitive control, and dopamine profoundly
influences its functions. In other brain regions, astrocytes sense diverse neurotransmitters …