ROS generation in microglia: understanding oxidative stress and inflammation in neurodegenerative disease
DSA Simpson, PL Oliver - Antioxidants, 2020 - mdpi.com
Neurodegenerative disorders, such as Alzheimer's disease, are a global public health
burden with poorly understood aetiology. Neuroinflammation and oxidative stress (OS) are …
burden with poorly understood aetiology. Neuroinflammation and oxidative stress (OS) are …
[HTML][HTML] V-ATPase Dysfunction in the Brain: Genetic Insights and Therapeutic Opportunities
Vacuolar-type ATPase (v-ATPase) is a multimeric protein complex that regulates H+
transport across membranes and intra-cellular organelle acidification. Catabolic processes …
transport across membranes and intra-cellular organelle acidification. Catabolic processes …
A comprehensive Drosophila resource to identify key functional interactions between SARS-CoV-2 factors and host proteins
Development of effective therapies against SARS-CoV-2 infections relies on mechanistic
knowledge of virus-host interface. Abundant physical interactions between viral and host …
knowledge of virus-host interface. Abundant physical interactions between viral and host …
Loss-of-function variants in TIAM1 are associated with developmental delay, intellectual disability, and seizures
Summary TIAM Rac1-associated GEF 1 (TIAM1) regulates RAC1 signaling pathways that
affect the control of neuronal morphogenesis and neurite outgrowth by modulating the actin …
affect the control of neuronal morphogenesis and neurite outgrowth by modulating the actin …
A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial–temporal regulation of histone arginine methylation in neurodevelopment
Abstract Background Oxidation Resistance 1 (OXR1) gene is a highly conserved gene of the
TLDc domain-containing family. OXR1 is involved in fundamental biological and cellular …
TLDc domain-containing family. OXR1 is involved in fundamental biological and cellular …
[HTML][HTML] Delivery of pOXR1 through an injectable liposomal nanoparticle enhances spinal cord injury regeneration by alleviating oxidative stress
Abstract Oxidation resistance 1 (OXR1) is regarded as a critical regulator of cellular
homeostasis in response to oxidative stress. However, the role of OXR1 in the neuronal …
homeostasis in response to oxidative stress. However, the role of OXR1 in the neuronal …
OXR1 maintains the retromer to delay brain aging under dietary restriction
Dietary restriction (DR) delays aging, but the mechanism remains unclear. We identified
polymorphisms in mtd, the fly homolog of OXR1, which influenced lifespan and mtd …
polymorphisms in mtd, the fly homolog of OXR1, which influenced lifespan and mtd …
Preventing neurodegeneration by controlling oxidative stress: the role of OXR1
MR Volkert, DJ Crowley - Frontiers in Neuroscience, 2020 - frontiersin.org
Parkinson's disease, diabetic retinopathy, hyperoxia induced retinopathy, and neuronal
damage resulting from ischemia are among the notable neurodegenerative diseases in …
damage resulting from ischemia are among the notable neurodegenerative diseases in …
GWAS for lifespan and decline in climbing ability in flies upon dietary restriction reveal decima as a mediator of insulin-like peptide production
KA Wilson, JN Beck, CS Nelson, TA Hilsabeck… - Current Biology, 2020 - cell.com
Dietary restriction (DR) is the most robust means to extend lifespan and delay age-related
diseases across species. An underlying assumption in the aging field is that DR enhances …
diseases across species. An underlying assumption in the aging field is that DR enhances …
The Ncoa7 locus regulates V-ATPase formation and function, neurodevelopment and behaviour
E Castroflorio, J Den Hoed, D Svistunova… - Cellular and Molecular …, 2021 - Springer
Abstract Members of the Tre2/Bub2/Cdc16 (TBC), lysin motif (LysM), domain catalytic (TLDc)
protein family are associated with multiple neurodevelopmental disorders, although their …
protein family are associated with multiple neurodevelopmental disorders, although their …