Covalent attachment of myristate and/or palmitate occurs on a wide variety of viral and
cellular proteins. This review will highlight the latest advances in our understanding of the …

Myristoylation corresponds to the irreversible covalent linkage of the 14-carbon saturated
fatty acid, myristic acid, to the N-terminal glycine of many eukaryotic and viral proteins. It is …

Prostate cancer is one of the most common malignant cancers in men. Recent studies have
shown that microRNA-21 (miR-21) is overexpressed in various types of cancers including …

The public health threat posed by a looming 'post-antibiotic'era necessitates new
approaches to antibiotic discovery. Drug development has typically avoided exploitation of …

The proteins of the MARCKS (myristoylated alanine-rich C kinase substrate) family were first
identified as prominent substrates of protein kinase C (PKC). Since then, these proteins …

Covalent lipid modifications anchor numerous signalling proteins to the cytoplasmic face of
the plasma membrane. These modifications mediate protein–membrane and protein …

The plasma membrane of most animal cells conforms to the cytoskeleton and only
occasionally separates to form blebs. Previous studies indicated that many weak …

The pore-forming hemolysin (HlyA) of Escherichia coli represents a unique class of bacterial
toxins that require a posttranslational modification for activity. The inactive protoxin pro-HlyA …

Many experimental, structural and computational studies have established the importance of
nonspecific electrostatics as a driving force for peripheral membrane association. Here we …

Protein kinases and phosphatases are targeted through association with anchoring proteins
that tether the enzymes to subcellular structures and organelles. Through in situ fluorescent …