Proteases are signaling molecules that specifically control cellular functions by cleaving
protease-activated receptors (PARs). The four known PARs are members of the large family …

The accumulating knowledge of the host-microbiota interplay gives rise to the microbiota-gut-
brain (MGB) axis. The MGB axis depicts the interkingdom communication between the gut …

Auch wurden ähnlich wie bei der Vorgängerleitlinie die Empfehlungen zum kindlichen
Reizdarmsyndrom und Empfehlungen zur Abgrenzung intestinaler Motilitätsstörungen …

Irritable bowel syndrome (IBS) is one of the most prevalent functional gastrointestinal
disorders, and accumulating evidence gained in both preclinical and clinical studies indicate …

Objective The intestinal lumen contains several proteases. Our aim was to determine the
role of faecal proteases in mediating barrier dysfunction and symptoms in IBS. Design 39 …

Protease‐activated receptors (PARs) are a unique class of G‐protein‐coupled
transmembrane receptors, which revolutionized the perception of proteases from …

Bifidobacterium longum, a common member of the gut microbiota throughout the human
lifespan, has been widely reported to play a role in host health and disease. However …

METHODS: Men and women with IBS-D by the Rome III criteria, Bristol Stool Scale≥ 6 on 2
or more days weekly, and average daily worst pain intensity≥ 3/10 were randomized 60: 40 …

Recent accessibility to specialized high-throughput “omics” technologies including single
cell RNA sequencing allows researchers to capture cell type-and subtype-specific …

Abstract The Serine Protease Inhibitor (serpin) protein has been suggested to play a key
role in the interaction of bifidobacteria with the host. By inhibiting intestinal serine proteases …